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  2. Raf family

Raf familyRaf 家族

释义:

Raf family are conserved, ubiquitous serine/protein kinases. The Raf protein kinases are key intermediates in cellular signal transduction, functioning as direct effectors of the RAS GTPases and as the initiating kinases in the Extracellular signal-regulated kinases (ERKs) cascade. Raf family includes A-Raf, B-Raf and C-Raf, possess a Ras-binding domain (RBD) in their N-terminal regulatory region and can function as effectors of active GTP-bound RAS family

Raf 家族是保守的、普遍存在的丝氨酸/蛋白激酶。Raf 蛋白激酶是细胞信号转导中的关键中间体,作为 RAS GTP 酶的直接效应物和 Extracellular signal-regulated kinases (ERKs) 级联中的起始激酶发挥作用。Raf 家族包括 A-Raf、B-Raf 和 C-Raf,在其 N 末端调节区中具有 Ras 结合结构域 (RBD),可作为活性 GTP 结合 RAS family 的效应子发挥作用。

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