2. Protein Tyrosine Kinase/RTK
  3. BRK
  4. BRK inhibitor P21d hydrochloride

BRK inhibitor P21d hydrochloride 

目录号: HY-115514A
COA 产品使用指南

摩尔计算器

BRK inhibitor P21d hydrochloride 是一种有效的乳腺肿瘤激酶 ( BRK/PTK6) 抑制剂，IC50 为 30 nM。BRK inhibitor P21d hydrochloride 抑制 p-SAM68，IC50 为 52 nM。BRK inhibitor P21d hydrochloride 可用于评估 BRK 抑制剂在异种移植乳腺肿瘤模型中的体内活性。

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BRK inhibitor P21d hydrochloride Chemical Structure

BRK inhibitor P21d hydrochloride Chemical Structure

CAS No. : 2250025-98-8

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规格 价格 是否有货
1 mg ￥3080
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BRK inhibitor P21d hydrochloride 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BRK inhibitor P21d hydrochloride is a potent breast tumor kinase (BRK/PTK6) inhibitor with an IC50 of 30 nM. BRK inhibitor P21d hydrochloride inhibits p-SAM68 with an IC50 of 52 nM. BRK inhibitor P21d hydrochloride can be used to evaluate the in vivo activity of BRK inhibitors in xenograft breast tumor models[1].

IC50 & Target

IC50: 30 nM (BRK), 52 nM (p-SAM68), >20 μM (Aurora B), >20 μM (Lck)[1]
体外研究
(In Vitro)

BRK inhibitor P21d hydrochloride (compound 21d) inhibits Aurora B (IC50>20 μM) and Lck (IC50>20 μM)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

BRK inhibitor P21d hydrochloride 相关抗体:
体内研究
(In Vivo)

BRK inhibitor P21d hydrochloride (compound 21d) has much better permeability (CACO-2:314 nm/s) and PK profile (rat, po, 10 mpk, AUC0–6h=31.1 μM•h,C6h=3.5 μM)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

483.93

Formula

C23H23ClFN7O2
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

纯度 & 产品资料
参考文献

BRK inhibitor P21d hydrochloride 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BRK inhibitor P21d2250025-98-8BRKBreast tumor kinaseProtein tyrosine kinase 6 (PTK6)breasttumorkinasePTK6p-SAM68Inhibitorinhibitorinhibit

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