2. Anti-infection Cell Cycle/DNA Damage
  3. Bacterial DNA/RNA Synthesis
  4. Evybactin

Evybactin 是 DNA 旋转酶 的抑制剂。Evybactin 是结核杆菌的选择性抑制剂，MIC 值为 0.25 µg/mL。Evybactin 是第一个被发现的具有这种选择性机制的抗菌化合物。

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Custom Peptide Synthesis

Evybactin Chemical Structure

Evybactin Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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Evybactin 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Evybactin is a DNA gyrase inhibitor. Evybactin is a selective inhibitor of Mycobacterium tuberculosis with a MIC value of 0.25 µg/mL. Evybactin is the first antimicrobial compound found to employ this unusual mechanism of selectivity[1].

IC50 & Target

IC50: 1 μM (DNA cleavage)[1]
体外研究
(In Vitro)

Evybactin (0-1000 µg/mL; 24 h) inhibits Mycobacterium tuberculosis with a MIC value of 0.25 µg/mL[1].
Evybactin (100 µM; 30 min) induces DNA cleavage with an IC50 value of 1 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Evybactin 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: HepG2, FaDu and HEK293 cell lines
Concentration: 0-1000 µg/mL
Incubation Time: 24 hours
Result: Showed no toxicity against HepG2, FaDu and HEK293 human cells with IC50s ＞128 µg/mL.
体内研究
(In Vivo)

Evybactin (25-100 mg/kg; i.p. once) effectively inhibits E. coli infection in vivo[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice with E. coli infection[1]
Dosage: 25 and 100 mg/kg
Administration: Intraperitoneal injection; 25 and 100 mg/kg once
Result: Showed significant efficacy with a single dose of 25 mg/kg, and protected mice from infection with a single dose of 100 mg/kg, whereas 83% of untreated control animals died in 24 hours.
分子量

1488.52

Formula

C64H89N21O21
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Evybactin 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EvybactinBacterialDNA/RNA SynthesishydrophilicBacAPhotorhabdus noenieputensisantibioticantimicrobialDNA cleavageInhibitorinhibitorinhibit

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目录号：
HY-P3473
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