BPNT1 - 3'(2'), 5'-bisphosphate nucleotidase 1 Gene

中文名称：3' (2') , 5'-二磷酸核苷酸酶 1

种属: Homo sapiens

同用名: PIP; HEL20

关于 BPNT1

功能概要

BPNT1，也称为二磷酸 3-引物核苷酸酶或 BPntase，是镁依赖性磷酸单酯酶家族的成员。锂是一种用于治疗躁狂抑郁症的主要药物，可作为 BPntase 的非竞争性抑制剂。预测的人类蛋白质与小鼠 BPntase 有 92% 的同一性。 BPntase 在核苷酸代谢中的生理作用可能受肌醇信号通路的调节。抑制人 BPntase 可能是锂诱导的肾毒性的原因。[RefSeq 提供，2008 年 7 月]

BPNT1, also called bisphosphate 3-prime-nucleotidase, or BPntase, is a member of a magnesium-dependent phosphomonoesterase family. Lithium, a major drug used to treat manic depression, acts as an uncompetitive inhibitor of BPntase. The predicted human protein is 92% identical to mouse BPntase. BPntase's physiologic role in nucleotide metabolism may be regulated by inositol signaling pathways. The inhibition of human BPntase may account for lithium-induced nephrotoxicity. [provided by RefSeq, Jul 2008]