FLRT2 - fibronectin leucine rich transmembrane protein 2 Gene

中文名称：纤连蛋白富亮氨酸跨膜蛋白 2

种属: Homo sapiens

关于 FLRT2

功能概要

该基因编码细胞粘附分子的纤连蛋白富含亮氨酸跨膜 (FLRT) 家族的成员，该家族调节早期胚胎血管和神经发育。编码的 I 型跨膜蛋白具有一个细胞外区域，该区域由一个 N 末端富含亮氨酸的重复结构域和一个 3 型纤连蛋白结构域组成，然后是一个跨膜结构域和一个短的 C 末端胞质尾结构域。它通过与不协调的 5 受体家族成员的相互作用，发挥嗜同细胞粘附分子和异嗜化学排斥剂的作用。细胞外区域的蛋白水解去除控制发育中皮层中神经元的迁移。可变剪接导致多个转录本变体。[RefSeq 提供，2016 年 9 月]

This gene encodes a member of the fibronectin leucine rich transmembrane (FLRT) family of cell adhesion molecules, which regulate early embryonic vascular and neural development. The encoded type I transmembrane protein has an extracellular region consisting of an N-terminal leucine-rich repeat domain and a type 3 fibronectin domain, followed by a transmembrane domain and a short C-terminal cytoplasmic tail domain. It functions as both a homophilic cell adhesion molecule and a heterophilic chemorepellent through its interaction with members of the uncoordinated-5 receptor family. Proteolytic removal of the extracellular region controls the migration of neurons in the developing cortex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]