1. Gene
  2. GLRX - glutaredoxin Gene

GLRX - glutaredoxin Gene

中文名称:谷氧还蛋白

种属: Homo sapiens

同用名: GRX; GRX1

基因 ID: 2745 | 基因类型: protein coding

关于 GLRX

Cytogenetic location: 5q15 Genomic coordinates (GRCh38): 5:95,813,849-95,822,726 (from NCBI)

This gene has 7 transcripts (splice variants) and 250 orthologues. Broad expression in kidney (RPKM 54.1), small intestine (RPKM 45.6) and 22 other tissues.

功能概要

该基因编码谷氧还蛋白家族的一个成员。编码的蛋白质是一种细胞质酶,可催化谷胱甘肽-蛋白质混合二硫化物的可逆还原。这种酶对抗氧化防御系统有很大贡献。通过控制信号介质的 S-谷胱甘肽化状态,它对几种信号通路至关重要。它与 β-淀粉样蛋白毒性和阿尔茨海默病有关。已经鉴定出编码相同蛋白质的多个选择性剪接的转录物变体。[RefSeq 提供,2011 年 8 月]

This gene encodes a member of the glutaredoxin family. The encoded protein is a cytoplasmic Enzyme catalyzing the reversible reduction of glutathione-protein mixed disulfides. This Enzyme highly contributes to the antioxidant defense system. It is crucial for several signalling pathways by controlling the S-glutathionylation status of signalling mediators. It is involved in beta-amyloid toxicity and Alzheimer's disease. Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Aug 2011]

GLRX 基因产物(4)

mRNA Protein Name
NM_001118890.2 NP_001112362.1 glutaredoxin-1
NM_001243658.2 NP_001230587.1 glutaredoxin-1
NM_001243659.2 NP_001230588.1 glutaredoxin-1
NM_002064.3 NP_002055.1 glutaredoxin-1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables glutathione disulfide oxidoreductase activity EXP
EXP: 通过实验结果推断
7851394 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16884690 GOA
enables sodium channel regulator activity IDA
IDA: 通过直接分析推断
19542013 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of membrane potential IDA
IDA: 通过直接分析推断
19542013 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

GLRX 蛋白结构

Glutaredoxin

Glutaredoxin: Glutaredoxin (15 - 80)

  • 0
  • 100
  • 106 a.a.
蛋白主名 其他名称

glutaredoxin-1

TTase-1

重组 GLRX 蛋白

目录号 产品名 蛋白编号 纯度
HY-P76366 GRX1/Glutaredoxin 1 Protein, Human (His) P35754 (M1-Q106) ≥95%

关联疾病

疾病名称 别名
Deafness, Autosomal Recessive 25

DFNB25

Autosomal Recessive Nonsyndromic Deafness 25

Autosomal Recessive Deafness 25

Deafness, Autosomal Recessive, 25

Deafness, Autosomal Recessive, Type 25

Pancreatic Cystadenocarcinoma

Cystadenocarcinoma Of Pancreas

Non-Syndromic X-Linked Intellectual Disability 1

Mrx1

Mrx18

Mrx78

X-Linked Mental Retardation 1/78

X-Linked Mental Retardation 18

Malaria

Malaria, Susceptibility To

Malaria, Resistance To

Malaria, Cerebral

Cerebral Malaria

Malaria, Severe, Susceptibility To

Malaria, Severe, Resistance To

Malaria, Cerebral, Susceptibility To

Induced Malaria

Malaria, Vivax, Protection Against

Malaria, Severe

Malaria, Cerebral, Reduced Risk Of

Malaria, Protection Against

Resistance To Malaria Due To G6pd Deficiency

Malaria Due To G6pd Deficiency

Malarial Encephalitis

CM

Malaria Cerebral

Susceptibility To Malaria

Acute Pernicious Fever

Aestivo-Autumnal Fever

Aestivo Autumnal Malaria

Chagres Fever

Continued Malaria Fever

Estivo-Autumnal Fever

Estivo-Autumnal Malaria

Estivo-Autumnal Malarial Fever

Falciparum Fever

Malignant Tertian Fever

Malignant Tertian Malaria

Pernicious Intermittent Fever

Pernicious Malaria

Quotidian Malaria

Subtertian Fever

Subtertian Malaria Fever

Subtertian Malignant Tertian Malaria

Tropical Malaria

Algid Malaria

Bilious Haemoglobinuric Fever

Black Water Fever

Blackwater Fever

Malarial Blackwater Fever

Severe Malarial Falciparum

West African Fever

Malarial Haematinuria

Haemoglobinuric Fever

Haemoglobinuric Malaria

Severe Plasmodium Falciparum Malaria

Malarial Haemoglobinuria

Malarial Haematuria

Falciparum Malaria [Malignant Tertian]

Malaria Tropica

Malarial Shock

Chagres Virus Disease

Malignant Malaria

Mtm - [Malignant Tertian Malaria]

Tm -[Malignant Tertian Malaria]

Panama Fever

St - [Subtertian Malaria]

Malarial Quotidian

Benign Tertian Malaria

Tertian Ague

Vivax Fever

Plasmodium Vivax Malaria Nos

Btm - [Benign Tertian Malaria]

Bt - [Benign Tertian Malaria]

Vivax Malaria

Benign Tertian Vivax Malaria

Tertian Malaria

Quartan Malaria

Quartan Ague

Quartan Fever

Plasmodium Malariae Malaria Nos

Quartan Malarial

Malaria By Plasmodium Malariae

Malariae Malaria

Ovale Tertian Malaria

Plasmodium Ovale Fever

Malaria Fever By Plasmodium Ovale

Ovale Malaria

Malaria By Plasmodium Ovale

Malarial Ovale

Marsh Fever

Remittent Congestive Fever

Coastal Fever

Remittent Gastric Fever

Miasmatic Fever

Congestive Remittent Fever

Intermittent Fever

Jungle Fever

Paludism

Cameroon Fever

Ague

Corsican Fever

Intermittent Bilious Fever

Disease Due To Plasmodiidae

Malarial Fever

Plasmodiosis

Remittent Fever

Roman Fever

Malaria Fever Nos

Malaria Nos

Paludal Fever

Clinically Diagnosed Malaria

Clinically Diagnosed Malaria Without Parasitological Confirmation

Congestive Fever

Malarial Cachexia

Marsh Cachexia

Paludal Cachexia

Recurrent Malaria

Remittent Malaria

Cortical Dysplasia, Complex, With Other Brain Malformations 6

Complex Cortical Dysplasia With Other Brain Malformations 6

CDCBM6

Cdcbm56

Dysplasia ,Cortical, Complex, With Other Brain Malformations, Type 6

Alzheimer Disease, Familial, 1

Alzheimer Disease

Alzheimer'S Disease

Presenile And Senile Dementia

AD1

Alzheimer Disease, Susceptibility To

Alzheimer Disease, Late-Onset, Susceptibility To

Alzheimer Disease 1, Familial

AD

Familial Alzheimer Disease

Alzheimer Disease, Late-Onset

Alzheimers Dementia

Alzheimer Dementia

Alzheimer Sclerosis

Alzheimer Syndrome

Alzheimer-Type Dementia

Dat

Primary Senile Degenerative Dementia

Sdat

Alzheimer Disease 1

Autosomal Dominant Alzheimer Disease

Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

Late Onset Alzheimer Disease

Alzheimers Disease

Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

Late-Onset Alzheimers Disease

Alzheimer'S Disease Pathway Kegg

Dementia Due To Alzheimer'S Disease

Alzheimer Disease Type 1

Alzheimers

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris GLRX VGNC VGNC:41273
Mus musculus GLRX MGD MGI:2135625
Macaca mulatta GLRX VGNC VGNC:84383
Rattus norvegicus GLRX RGD RGD:70951
Others GLRX NCBI