2. Gene
  3. GPR6 - G protein-coupled receptor 6 Gene

GPR6 - G protein-coupled receptor 6 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：G 蛋白偶联受体 6

种属: Homo sapiens

基因 ID: 2830 | 基因类型: protein coding

关于 GPR6

Cytogenetic location: 6q21 Genomic coordinates (GRCh38): 6:109,978,311-109,980,720 (from NCBI)

This gene has 2 transcripts (splice variants), 186 orthologues and 18 paralogues. Low expression observed in reference dataset.

功能概要

预计可启用鞘氨醇-1-磷酸受体活性。预计参与腺苷酸环化酶激活 G 蛋白偶联受体信号通路和代谢过程的调控。预计在细胞溶质钙离子浓度的正调节上游或正调节内起作用。预计是质膜的组成部分。预计在细胞质和质膜中有活性。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable sphingosine-1-phosphate receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and regulation of metabolic process. Predicted to act upstream of or within positive regulation of cytosolic calcium ion concentration. Predicted to be integral component of plasma membrane. Predicted to be active in cytoplasm and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

GPR6 基因产物(2)

mRNA Protein Name
NM_005284.5 NP_005275.1 G-protein coupled receptor 6 isoform b
NM_001286099.2 NP_001273028.1 G-protein coupled receptor 6 isoform a

GPR6 蛋白结构

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (89 - 329)

  • 0
  • 100
  • 200
  • 300
  • 362 a.a.
蛋白主名 其他名称

G-protein coupled receptor 6

sphingosine 1-phosphate receptor GPR6

关联疾病

疾病名称 别名
Lennox-Gastaut Syndrome

Epileptic Encephalopathy Lennox-Gastaut Type

Lennox Syndrome

Encephalopathy Of Childhood

Childhood Epileptic Encephalopathy With Diffuse Slow Spikes And Waves

Lgs
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-134661A CVN424 99.70% Phase 2
Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-134661 (S)-CVN424 / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus GPR6 MGD MGI:2155249
Canis familiaris GPR6 VGNC VGNC:41439
Felis catus GPR6 VGNC VGNC:67435
Bos taurus GPR6 VGNC VGNC:29592
Macaca mulatta GPR6 VGNC VGNC:73139
Rattus norvegicus GPR6 RGD RGD:70939
Others GPR6 NCBI
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