CLEC4G - C-type lectin domain family 4 member G Gene

中文名称：C 型凝集素结构域家族 4 成员 G

种属: Homo sapiens

同用名: LP2698; UNQ431; DTTR431; LSECtin

关于 CLEC4G

功能概要

该基因编码聚糖结合受体和 C 型凝集素家族的成员，后者在免疫反应中发挥作用。 C 型凝集素受体是位于免疫细胞上的模式识别受体，在识别和摄取自身和非自身糖蛋白以及介导细胞粘附、糖蛋白清除和细胞信号传导功能方面发挥作用。该基因的蛋白质结合埃博拉病毒、西尼罗河丝状病毒和 SARS 冠状病毒的病毒包膜蛋白的复合型 N-聚糖，但不结合 HIV 或丙型肝炎病毒。在小鼠中，这种蛋白质已被证明可以识别活化的 T 细胞并负向调节 T 细胞受体介导的信号传导。它还充当小鼠 NK 细胞介导免疫的新型肝脏特异性调节剂。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2020 年 4 月]

This gene encodes a glycan-binding receptor and member of the C-type lectin family which plays a role in the immune response. C-type Lectin Receptors are Pattern Recognition Receptors located on immune cells that play a role in the recognition and uptake of both self and non-self glycoproteins as well as mediating cell adhesion, glycoprotein clearance, and cell signaling functions. This gene's protein binds complex-type N-glycans of the viral envelope proteins of Ebola virus, West Nile Filovirus, and SARS coronavirus, but not HIV or hepatitis C virus. In mouse, this protein has been shown to recognize activated T-cells and to negatively regulate T-cell receptor-mediated signalling. It also acts as a novel, liver-specific regulator of NK cell-mediated immunity in mouse. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2020]