ING4 - inhibitor of growth family member 4 Gene

中文名称：生长抑制因子家族成员 4

种属: Homo sapiens

同用名: my036; p29ING4

关于 ING4

功能概要

该基因编码含有 PHD 指的肿瘤抑制蛋白，这是参与染色质重塑的蛋白质中的常见基序。这种蛋白质可以结合 TP53 和 EP300/p300，后者是组蛋白乙酰转移酶复合物的一个组成部分，表明它参与了 TP53 依赖性调节通路。已观察到编码不同蛋白质的多个选择性剪接转录物变体。[RefSeq 提供，2008 年 7 月]

This gene encodes a tumor suppressor protein that contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in the TP53-dependent regulatory pathway. Multiple alternatively spliced transcript variants have been observed that encode distinct proteins. [provided by RefSeq, Jul 2008]