PRG2 - proteoglycan 2, pro eosinophil major basic protein Gene

中文名称：蛋白多糖 2，嗜酸性粒细胞原主要碱性蛋白

种属: Homo sapiens

同用名: MBP; BMPG; MBP1; proMBP

基因 ID: 5553 | 基因类型: protein coding

关于 PRG2

Cytogenetic location: 11q12.1 Genomic coordinates (GRCh38): 11:57,386,780-57,390,650 (from NCBI)

This gene has 4 transcripts (splice variants), 98 orthologues and 1 paralogue. Restricted expression toward placenta (RPKM 1164.9).

功能概要

由该基因编码的蛋白质是嗜酸性粒细胞结晶核的主要成分。这种蛋白质的高水平形式也存在于胎盘和妊娠血清中，它以与其他几种蛋白质的复合物形式存在，包括妊娠相关血浆蛋白 A (PAPPA) 、血管紧张素原 (AGT) 和 C3dg。这种蛋白质可能作为细胞毒素和蠕虫毒素参与抗寄生虫防御机制，并参与免疫超敏反应。编码的蛋白质包含一种肽，该肽对革兰氏阳性菌、革兰氏阴性菌和真菌显示出强大的抗菌活性。它直接涉及过敏性疾病中的上皮细胞损伤、脱落和支气管痉挛。已发现该基因编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2014 年 11 月]

The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), Angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions. The encoded protein contains a peptide that displays potent antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria, and fungi. It is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]

PRG2 基因产物(4)

mRNA	Protein	Name
NM_001243245.3	NP_001230174.1	bone marrow proteoglycan isoform 2 preproprotein
NM_001302926.2	NP_001289855.1	bone marrow proteoglycan isoform 1 preproprotein
NM_001302927.2	NP_001289856.1	bone marrow proteoglycan isoform 1 preproprotein
NM_002728.6	NP_002719.3	bone marrow proteoglycan isoform 1 preproprotein

PRG2 蛋白结构

Lectin_C

0
100
200
222 a.a.

蛋白主名

其他名称

bone marrow proteoglycan

eosinophil granule major basic protein

重组 PRG2 蛋白

目录号	产品名	蛋白编号	纯度
HY-P7672	BMPG Protein, Human (HEK293, His)	AAH05929.1 (L17-Y222 )	≥95%

关联疾病

疾病名称

别名

Hypereosinophilic Syndrome

Eosinophilia	HES
Eosinophilic Leukocytosis	Hypereosinophilic Syndrome, Idiopathic
Idiopathic Hypereosinophilic Syndrome	Disseminated Eosinophilic Collagen Disease
Eosinophilic Disorder	Disorders With Increased Eosinophil Counts

Dermatographia

Dermatographic Urticaria	Dermographism
Symptomatic Dermographism	Urticaria Factitia
Factitious Urticaria	Dermatographism

Conidiobolomycosis

Infection By Conidiobolus	Rhinoentomophthoromycosis
Entomophthoromycosis Conidiobolae

Esophagitis

Acute Esophagitis

Churg-Strauss Syndrome

Eosinophilic Granulomatosis With Polyangiitis	Allergic Granulomatous Angiitis
Churg-Strauss Vasculitis	Allergic Angiitis
Egpa	Granulomatous Allergic Angiitis
Allergic Granulomatosis Angiitis	Allergic Angiitis And Granulomatosis
Allergic Granulomatosis	Allergic Granulomatous And Angiitis
Css

Urticaria

Nettle Rash	Hives
Wheal	Urticaria Nos

Rhinitis

Runny Nose

Colon Sarcoma

Colonic Sarcoma

Loeffler Endocarditis

Eosinophilic Endomyocardial Disease	Eosinophilic Endocarditis
Loeffler'S Endocarditis	Primary Eosinophilic Endomyocardial Restrictive Cardiomyopathy

Pulmonary Eosinophilia

Asthmatic Pulmonary Eosinophilia	Eosinophilic Lung Infiltrate
Weingarten'S Syndrome

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Gastroenteritis

Cholera Morbus	Infectious Colitis, Enteritis And Gastroenteritis
Enteritis Due To Astrovirus	Rotaviral Gastroenteritis
Viral Gastroenteritis Due To Rotavirus

Schizophrenia 13

SCZD13	Schizophrenia Susceptibility Locus, Chromosome 15q13-Q14-Related
Schizophrenia, Susceptibility To, 13

Loeffler Syndrome

Loeffler'S Pneumonia	Loffler'S Syndrome
Simple Pulmonary Eosinophilia

Dermatitis, Atopic

Atopic Dermatitis	Atopic Eczema
Dermatitis, Atopic, Susceptibility To, 1	Atod
Eczema, Atopic	Dermatitis, Atopic 1
Allergic Dermatitis	Atopic Neurodermatitis
Besnier'S Prurigo	Dermatitis, Atopic, 1
Dermatitis Atopic	Eczema
Besnier Prurigo

Endomyocardial Fibrosis

Becker'S Disease	Obscure African Cardiomyopathy
African Endomyocardial Fibrosis	Endomyocardial Sclerosis
EMF	Becker Muscular Dystrophy

Myiasis

Infestation By Fly Larvae	Infestation By Maggots
Maggot Infestation	Infestation By Larvae Of Flies
Infestation By Dermatobia	Infestation By Estrus Ovis
Infestation By Oestrus Ovis	Oestriasis
Oestrosis

Esophagitis, Eosinophilic, 1

Eosinophilic Esophagitis	EOE1
Esophagitis, Eosinophilic	Ee

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS11088	PRG2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	PRG2	MGD	MGI:103294
Rattus norvegicus	PRG2	RGD	RGD:69336

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

PRG2 - proteoglycan 2, pro eosinophil major basic protein Gene

关于 PRG2

功能概要

PRG2 基因产物(4)

PRG2 蛋白结构

重组 PRG2 蛋白

关联疾病

直系同源

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PRG2 - proteoglycan 2, pro eosinophil major basic protein Gene

关于 PRG2

功能概要

PRG2 基因产物(4)

PRG2 蛋白结构

重组 PRG2 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z