1. Gene
  2. THBS4 - thrombospondin 4 Gene

THBS4 - thrombospondin 4 Gene

中文名称:血小板反应蛋白 4

种属: Homo sapiens

同用名: TSP4; TSP-4

基因 ID: 7060 | 基因类型: protein coding

关于 THBS4

Cytogenetic location: 5q14.1 Genomic coordinates (GRCh38): 5:79,991,332-80,083,287 (from NCBI)

This gene has 7 transcripts (splice variants), 281 orthologues and 5 paralogues. Biased expression in fat (RPKM 161.8), heart (RPKM 56.3) and 1 other tissue.

功能概要

该基因编码的蛋白质属于血小板反应蛋白家族。血小板反应蛋白家族成员是粘附糖蛋白,可介导细胞与细胞和细胞与基质的相互作用。这种蛋白质形成五聚体,可以与肝素和钙结合。它参与发育中和成人神经系统的局部信号传导,并有助于脊柱敏化和神经性疼痛状态。该基因在对浸润性乳腺癌的基质反应过程中被激活。它还可能在阿尔茨海默病的炎症反应中发挥作用。可变剪接导致多个转录本变体。[RefSeq 提供,2015 年 4 月]

The protein encoded by this gene belongs to the thrombospondin protein family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentamer and can bind to heparin and calcium. It is involved in local signaling in the developing and adult nervous system, and it contributes to spinal sensitization and neuropathic pain states. This gene is activated during the stromal response to invasive breast Cancer. It may also play a role in inflammatory responses in Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

THBS4 基因产物(4)

mRNA Protein Name
NM_001306212.2 NP_001293141.1 thrombospondin-4 isoform b
NM_001306213.2 NP_001293142.1 thrombospondin-4 isoform b
NM_001306214.2 NP_001293143.1 thrombospondin-4 isoform b
NM_003248.6 NP_003239.2 thrombospondin-4 isoform a precursor

THBS4 蛋白结构

COMP

COMP: Cartilage oligomeric matrix protein (218 - 262)

EGF_CA

EGF_CA: Calcium-binding EGF domain (326 - 358)

EGF_CA

EGF_CA: Calcium-binding EGF domain (379 - 414)

TSP_3

TSP_3: Thrombospondin type 3 repeat (496 - 531)

TSP_3

TSP_3: Thrombospondin type 3 repeat (555 - 590)

TSP_3

TSP_3: Thrombospondin type 3 repeat (591 - 613)

TSP_3

TSP_3: Thrombospondin type 3 repeat (615 - 651)

TSP_3

TSP_3: Thrombospondin type 3 repeat (653 - 691)

TSP_3

TSP_3: Thrombospondin type 3 repeat (692 - 726)

TSP_C

TSP_C: Thrombospondin C-terminal region (745 - 945)

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  • 961 a.a.
蛋白主名 其他名称

thrombospondin-4

关联疾病

疾病名称 别名
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer

Mycetoma

Madura Foot

Mycetoma Of Foot

Nephroma

Benign Nephroma

Breast Giant Fibroadenoma

Giant Fibroadenoma

Giant Fibroadenoma Of Breast

Myocardial Infarction

Heart Attack

Myocardial Infarction, Susceptibility To

Myocardial Infarction 1

Myocardial Infarction, Protection Against

Myocardial Infarction, Decreased Susceptibility To

Myocardial Infarction, Decreased

Myocardial Infarct

MCI1

Premature Myocardial Infarction

Myocardial Infarction, Susceptibility To, Type 1

Multiple Epiphyseal Dysplasia

Med

Polyepiphyseal Dysplasia

Edm

Epiphyseal Dysplasia, Multiple, 1

Epiphyseal Dysplasia, Multiple, 2

Epiphyseal Dysplasia, Multiple, 3

Epiphyseal Dysplasia, Multiple, 4

Epiphyseal Dysplasia, Multiple, 5

Epiphyseal Dysplasia, Multiple

Edm1

Edm2

Edm3

Edm4

Edm5

Epiphyseal Dysplasia, Fairbank Type

Epiphyseal Dysplasia, Ribbing Type

Multiple Epiphyseal Dysplasia, Autosomal Dominant

Multiple Epiphyseal Dysplasia, Autosomal Recessive

Rmed

Dysplasia, Epiphyseal, Multiple

Osteochondrodysplasias

Fibrochondrogenesis

Fbcg1

Fbcg2

Fibrochondrogenesis-1

Fibrochondrogenesis-2

Fibrochondrogenesis 1

Fibrochondrogenesis 2

Lipoprotein Quantitative Trait Locus

Coronary Artery Disease

Coronary Artery Anomaly

Coronary Artery Disease, Susceptibility To

Myocardial Ischemia

Congenital Anomaly Of Coronary Artery

Coronary Arteriosclerosis

Coronary Disease

Coronary Heart Disease

Coronary Artery Disorder

LPAQTL

Lpa Deficiency, Congenital

Coronary Artery Abnormality

Coronary Artery Anomaly, Congenital

Chd

Coronary Syndrome

Congenital Malformations Of Coronary Vessels

Malformation Of Coronary Vessels

Congenital Coronary Artery Anomaly

Congenital Coronary Artery Deformity

Congenital Coronary Artery Disorder

Abnormal Coronary Artery

Congenital Coronary Artery Malposition

Congenital Coronary Disease

Congenital Anomaly Of Coronary Arteries

Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus THBS4 RGD RGD:62046
Canis familiaris THBS4 VGNC VGNC:47338
Macaca mulatta THBS4 VGNC VGNC:78346
Mus musculus THBS4 MGD MGI:1101779
Felis catus THBS4 VGNC VGNC:66157
Bos taurus THBS4 VGNC VGNC:35831