2. Gene
  3. TRIM46 - tripartite motif containing 46 Gene

TRIM46 - tripartite motif containing 46 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含三方基序 46

种属: Homo sapiens

同用名: GENEY; TRIFIC

基因 ID: 80128 | 基因类型: protein coding

关于 TRIM46

Cytogenetic location: 1q22 Genomic coordinates (GRCh38): 1:155,173,849-155,184,971 (from NCBI)

This gene has 10 transcripts (splice variants), 271 orthologues and 80 paralogues. Broad expression in brain (RPKM 2.5), testis (RPKM 0.9) and 14 other tissues.

功能概要

该基因编码三联基序 (TRIM) 家族的蛋白质。 TRIM 基序包括锌结合域、无名指区域、B 盒基序和卷曲螺旋域。据报道，TRIM46 参与多种类型癌细胞的增殖，包括肺癌和乳腺癌。它还被证明可以通过在轴突中形成均匀的微管束来控制神经元极性和轴突规格。[RefSeq 提供，2022 年 5 月]

This gene encodes a protein of the tripartite motif (TRIM) family. The TRIM motif includes zinc-binding domains, a RING finger region, a B-box motif and a coiled-coil domain. TRIM46 is reported to be involved in the proliferation of multiple types of Cancer cells including lung and breast Cancer. It has also been shown to control neuronal polarity and axon specification by forming uniform microtubule bundles in the axon. [provided by RefSeq, May 2022]

TRIM46 基因产物(9)

mRNA Protein Name
NM_001256599.2 NP_001243528.1 tripartite motif-containing protein 46 isoform 2
NM_001256601.1 NP_001243530.1 tripartite motif-containing protein 46 isoform 4
NM_001282378.2 NP_001269307.1 tripartite motif-containing protein 46 isoform 5
NM_001282379.2 NP_001269308.1 tripartite motif-containing protein 46 isoform 6
NM_001406245.1 NP_001393174.1 tripartite motif-containing protein 46 isoform 3
NM_001406246.1 NP_001393175.1 tripartite motif-containing protein 46 isoform 7
NM_001406247.1 NP_001393176.1 tripartite motif-containing protein 46 isoform 8
NM_001406256.1 NP_001393185.1 tripartite motif-containing protein 46 isoform 2
NM_025058.5 NP_079334.3 tripartite motif-containing protein 46 isoform 1

TRIM46 蛋白结构

zf-C3HC4

zf-C3HC4: Zinc finger, C3HC4 type (RING finger) (33 - 62)

zf-B_box

zf-B_box: B-box zinc finger (225 - 263)

  • 0
  • 200
  • 400
  • 600
  • 759 a.a.
蛋白主名 其他名称

tripartite motif-containing protein 46

gene Y protein

关联疾病

疾病名称 别名
Inflammatory Bowel Disease 2

IBD2
Phosphoribosylpyrophosphate Synthetase Superactivity

PRPS1 SUPERACTIVITY

Prpp Synthetase Superactivity

Gout, Prps-Related

Prpp Synthetase Deficiency

Prpp Synthetase Overactivity

Prs Overactivity

Prs Superactivity

Mild Phosphoribosylpyrophosphate Synthetase Superactivity

Mild Prpp Synthetase Superactivity

Mild Prps1 Superactivity

Severe Phosphoribosylpyrophosphate Synthetase Superactivity

Severe Prpp Synthetase Superactivity

Severe Prps1 Superactivity

Prps-Related Gout

Superactivity, Phosphoribosylpyrophosphate Synthetase
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15050 TRIM46 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus TRIM46 RGD RGD:1305993
Bos taurus TRIM46 VGNC VGNC:36338
Felis catus TRIM46 VGNC VGNC:66542
Mus musculus TRIM46 MGD MGI:2673000
Macaca mulatta TRIM46 VGNC VGNC:79170
Canis familiaris TRIM46 VGNC VGNC:47825
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