2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. LY-503430

LY-503430 是一种具有口服活性的 AMPA 受体正变构调节剂。LY-503430 可用于研究帕金森病。

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LY-503430 Chemical Structure

LY-503430 Chemical Structure

CAS No. : 625820-83-9

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LY-503430 相关抗体

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AMPA Receptor NMDA Receptor Kainate Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LY-503430 is an orally active AMPA receptor positive allosteric modulator (PAM). LY-503430 can be used for the study of Parkinson's disease[1].

体外研究
(In Vitro)

亚微摩尔浓度的 LY-503430（0.03-10 μM）选择性地增强谷氨酸诱导的钙流入转染了人 GLUA1、GLUA2、GLUA3 或 GLUA4 AMPA 受体的人胚胎肾 293 细胞。LY-503430 还能增强原生皮质、海马和黑质神经元中 AMPA 介导的反应[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

LY-503430 相关抗体:
体内研究
(In Vivo)

LY503430（0.5 mg/kg；皮下注射；每天一次；连续 11 天）在帕金森病啮齿动物模型中具有功能性、神经保护性和神经营养作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57Bl6J mice (20-25 g) injected with MPTP (HY-15608)[1]
Dosage: 0.5 mg/kg
Administration: s.c; once a day; for 11 days
Result: Prevention of MPTP-induced neurotoxicity in mice.
分子量

392.49

Formula

C20H25FN2O3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

LY-503430 相关分类

  • 摩尔计算器

  • 稀释计算器

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LY-503430625820-83-9LY503430LY 503430iGluRIonotropic glutamate receptorsAMPA receptor PAMParkinson's diseaseorally activeInhibitorinhibitorinhibit

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产品名称：
LY-503430
目录号：
HY-122164
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