2. JAK/STAT Signaling Stem Cell/Wnt Apoptosis
  3. STAT Apoptosis
  4. LY5

LY5 是 STAT3 的抑制剂，IC50 值为 0.5 μM。LY5 诱导细胞凋亡并抑制 STAT3 磷酸化。LY5 具有体内抗肿瘤活性，可用于癌症的研究。

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LY5 Chemical Structure

LY5 Chemical Structure

CAS No. : 1436382-03-4

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规格 价格 是否有货
5 mg ￥1900
询问价格 & 货期
10 mg ￥3200
询问价格 & 货期
25 mg 现货 询问价格 & 货期

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Customer Review

LY5 相关抗体

Top Publications Citing Use of Products

查看 STAT 亚型特异性产品:

查看所有亚型
STAT3 STAT5 STAT6 STAT1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LY5 is a STAT3 inhibitor with an IC50 value of 0.5 μM. LY5 induces apoptosis and inhibits STAT3 phosphorylation. LY5 shows antitumor activity in vivo, it can be used for the research of cancer[1].

IC50 & Target

IC50: 0.5 μM (STAT3)[1]
体外研究
(In Vitro)

LY5 shows inhibition effects to U2OS, RH30 and RD2 cancer cells with IC50 values of 0.52, 0.55 and 1.39 μM, respectively[1].
LY5 (0.25-1 μM; 16 h) induces apoptosis and inhibits STAT3 phosphorylation in human sarcoma cancer cells[1].
LY5 (0.25-1 μM; 5 h) inhibits STAT3 phosphorylation induced by IL-6[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

LY5 相关抗体:

Western Blot Analysis[1]

Cell Line: RH30 and EW8 cell lines
Concentration: 0.25-1 μM
Incubation Time: 16 hours
Result: Completely inhibited Tyr705 phosphorylation at 0.5 μM and dose-dependently decreased in formation of P-STAT3.
体内研究
(In Vivo)

LY5 (5 mg/kg; i.p. once daily for 21 days) inhibits breast tumor growth in vivo[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nude mice with MDA-MB-231 cancer cells injection[1]
Dosage: 5 mg/kg
Administration: Intraperitoneal injection; 5 mg/kg; once daily; for 21 days
Result: Suppressed tumor growth and significantly reduced the tumor sizes.
分子量

329.33

Formula

C15H11N3O4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

LY5 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LY51436382-03-4LY 5LY-5STATApoptosisapoptosisphosphorylationantitumorcancerU2OSRH30RD2IL-6miceInhibitorinhibitorinhibit

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