2. Immunology/Inflammation
  3. Toll-like Receptor (TLR) NO Synthase
  4. Macrophage-activating lipopeptide 2

Macrophage-activating lipopeptide 2  (Synonyms: MALP-2)

目录号: HY-P10586
产品使用指南

摩尔计算器

Macrophage-activating lipopeptide 2 (MALP-2) 是一种脂肽 Toll 样受体 TLR-2/TLR-6 激动剂。Macrophage-activating lipopeptide 2 可以增强内皮一氧化氮合酶 (eNOS) 磷酸化和内皮细胞释放 NO，从而改善血管舒张。Macrophage-activating lipopeptide 2 可以增强白细胞的内皮粘附，可以改善接受实验性股动脉结扎 (FAL) 的高胆固醇血症 Apoe 缺陷小鼠后肢的灌注恢复和侧支生长。

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Macrophage-activating lipopeptide 2 Chemical Structure

Macrophage-activating lipopeptide 2 Chemical Structure

CAS No. : 250718-44-6

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Macrophage-activating lipopeptide 2 相关抗体

Top Publications Citing Use of Products

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Macrophage-activating lipopeptide 2 (MALP-2) is an agonist of Toll like receptors TLR-2/TLR-6. Macrophage-activating lipopeptide-2 can enhance endothelial nitric oxide synthase (eNOS) phosphorylation and endothelial cell release of NO, thereby improving vasodilation. Macrophage-activating lipopeptide-2 can enhance endothelial adhesion of white blood cells and improve perfusion recovery and collateral growth in the hind limbs of hypercholesterolemic Apoe deficient mice undergoing experimental femoral artery ligation (FAL)[1].
IC50 & Target

TLR2

 

TLR6

 

体外研究
(In Vitro)

Macrophage-activating lipopeptide 2 (1 µg/mL, 24 h) 可以促进主要内皮粘附分子及白细胞整合素受体的表达，从而增强白细胞的内皮粘附[1]。
Macrophage-activating lipopeptide 2 (1 µg/mL, 2 h) 可以促进内皮 MyEnd 细胞中蛋白激酶 B 和 eNOS 的磷酸化，从而促进 NO 释放[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Macrophage-activating lipopeptide 2 相关抗体:

RT-PCR[1].

Cell Line: Endothelial MyEnd cells
Concentration: 1 µg/mL
Incubation Time: 24 h
Result: Caused a strong transient increase in mRNA levels of vascular cell adhesion molecule-1 (Vcam-1) after 1 hour, and also increased the levels of other major endothelial adhesion molecules, namely intercellular adhesion molecule-1 (Icam-1), E-selectin, and P-selectin, between 1-3 hours.

Western Blot Analysis[1].

Cell Line: Endothelial MyEnd cells
Concentration: 1 µg/mL
Incubation Time: 2 h
Result: Promoted phosphorylation of protein kinase B and eNOS.
体内研究
(In Vivo)

Macrophage-activating lipopeptide 2 (1 µg 溶于 125 µL PBS 中; 每天 1 次; 10 天; 静脉注射) 可以改善接受实验性股动脉结扎 (FAL) 的高胆固醇血症 Apoe 缺陷小鼠后肢的灌注恢复和侧支生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-10 weeks old male C57BL/6 Hypercholesterolemic Apoe-deficient mice[1].
Dosage: 1 µg in 125 µL PBS
Administration: Intravenous injection (i.v.); once daily; 10 days
Result: Improved blood flow recovery and increased the growth of pre-existing collateral arteries in the upper and hind limbs, as well as the proliferation of endothelial cells and accumulation of peri collagenous macrophages in the collateral walls.
分子量

2135.56

Formula

C99H167N19O30S
CAS 号
Sequence

{S-[(2R)-2,3-bis[(1-oxohexadecyl)oxy]propyl]Cys}-Gly-Asn-Asn-Asp-Glu-Ser-Asn-Ile-Ser-Phe-Lys-Glu-Lys
Sequence Shortening

{S-[(2R)-2,3-bis[(1-oxohexadecyl)oxy]propyl]Cys}-GNNDESNISFKEK
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Macrophage-activating lipopeptide 2 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Macrophage-activating lipopeptide 2250718-44-6MALP-2MALP2MALP 2Toll-like Receptor (TLR)NO SynthaseNitric oxide synthasesNOSToll-like receptorMyEnd cellendothelial adhesioncollateral growthInhibitorinhibitorinhibit

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