2. Academic Validation
  3. Funalenone, a novel collagenase inhibitor produced by Aspergillus niger

Funalenone, a novel collagenase inhibitor produced by Aspergillus niger

  • J Antibiot (Tokyo). 1999 Dec;52(12):1095-100. doi: 10.7164/antibiotics.52.1095.
J Inokoshi 1,  K Shiomi,  R Masuma,  H Tanaka,  H Yamada,  S Omura
Affiliations

Affiliation

  • 1 School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.
PMID: 10695672 DOI: 10.7164/antibiotics.52.1095
Abstract

Funalenone, a phenalene compound that inhibits type I collagenase (MMP-1), was isolated from mycelium of Aspergillus niger FO-5904 by solvent extaction, ODS column chromatography, Sephadex LH-20 column chromatography and reversed phase HPLC. Funalenone inhibited 50% of type I collagenase activity at a concentration of 170 microM, but inhibited 18.3% and 38.7% against 72 kDa and 92 kDa type IV collagenase, respectively, at a concentration of 400 microM.

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