[Elektrophysiological parameters of mollusk neurons under the influence of etimizol]

Extracellular application of 5--10 mM/L etimizol exerted a specific effect on the giant neurons of the Coretus corneus isolated nervous system: action potential duration increased significantly, speed of development of its descending phase decreased, as well as the trace hyperpolarization amplitude. The effect was reversible and depended upon the etimizol concentration and the initial functional state of neurons. Etimizol is supposed to decrease the K-+ permeability of neurons' membrane during action potential. Large concentrations of etimizol decrease, probably, the Na+ permeability as well as suggested by reducing maximum of the ascending phase of action potential.