2. Academic Validation
  3. Synthesis of 7-O-(2-deoxy-2-sulfamido-alpha-D-glucopyranosyl)-4-methylcoumarin sodium salt: a fluorogenic substrate for sulfamidase

Synthesis of 7-O-(2-deoxy-2-sulfamido-alpha-D-glucopyranosyl)-4-methylcoumarin sodium salt: a fluorogenic substrate for sulfamidase

  • Carbohydr Res. 2002 Jun 5;337(11):1055-8. doi: 10.1016/s0008-6215(02)00088-5.
Falguni Dasgupta 1,  R Irene Masada
Affiliations

Affiliation

  • 1 BioMarin Pharmaceutical Inc., 11 Pimentel Court, Novato, CA 94949, USA. fdcarbo@hotmail.com
PMID: 12039548 DOI: 10.1016/s0008-6215(02)00088-5
Abstract

The title compound, useful for testing the efficacy of heparin sulfamidase, was synthesized in good yield starting from 2-azido-2-deoxy-3,4,6-tri-O-acetyl-D-glucopyranosyl fluoride, reducing the azido group efficiently with SnCl(2)-PhSH-Et(3)N reagent and finally crystallizing the N-sulfated product from methanol after deacetylation.

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