2. Academic Validation
  3. Kigamicins, novel antitumor antibiotics. I. Taxonomy, isolation, physico-chemical properties and biological activities

Kigamicins, novel antitumor antibiotics. I. Taxonomy, isolation, physico-chemical properties and biological activities

  • J Antibiot (Tokyo). 2003 Dec;56(12):1004-11. doi: 10.7164/antibiotics.56.1004.
Setsuko Kunimoto 1,  Jie Lu,  Hiroyasu Esumi,  Yohko Yamazaki,  Naoko Kinoshita,  Yoshiko Honma,  Masa Hamada,  Michiyo Ohsono,  Masaaki Ishizuka,  Tomio Takeuchi
Affiliations

Affiliation

  • 1 Microbial Chemistry Research Center, Numazu Bio-Medical Research Institute, 18-24 Miyamoto, Numazu-shi, Shizuoka 410-0301, Japan. kunimotos@bikaken.or.jp
PMID: 15015727 DOI: 10.7164/antibiotics.56.1004
Abstract

Novel Antibiotics named kigamicin A, B, C, D, and E were discovered from the culture broth of Amycolatopsis sp. ML630-mF1 by their selective killing activity against PANC-1 cells only under a nutrient starved condition. Under a condition of nutrient starvation, kigamicins A, B, C, and D inhibited PANC-1 cell survival at 100 times lower concentration than in normal culture. Kigamicins showed antimicrobial activity against Gram-positive bacteria including methicillin resistant Staphylococcus aureus (MRSA). Kigamicin D inhibited the growth of various mouse tumor cell lines at IC50 of about 1 microg/ml.

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