2. Academic Validation
  3. Fungal phenalenones inhibit HIV-1 integrase

Fungal phenalenones inhibit HIV-1 integrase

  • J Antibiot (Tokyo). 2005 Jan;58(1):65-8. doi: 10.1038/ja.2005.8.
Kazuro Shiomi 1,  Ryosuke Matsui,  Miki Isozaki,  Harumi Chiba,  Takahiro Sugai,  Yuichi Yamaguchi,  Rokuro Masuma,  Hiroshi Tomoda,  Tomoko Chiba,  Hua Yan,  Yoshihiro Kitamura,  Wataru Sugiura,  Satoshi Omura,  Haruo Tanaka
Affiliations

Affiliation

  • 1 School of Pharmaceutical Sciences, Kitasato University, Minato-ku, Tokyo 108-8641, Japan.
PMID: 15813183 DOI: 10.1038/ja.2005.8
Abstract

A phenalenone compound, atrovenetinone methyl acetal, was isolated from a culture broth of Penicillium sp. FKI-1463 as an HIV-1 integrase inhibitor, and it showed anti-HIV activity in vitro. HIV-1 integrase inhibition and anti-HIV activity of two other natural phenalenones were also studied. Among the tested compounds, funalenone inhibited HIV-1 integrase with an IC50 value of 10 microM and showed the best selectivity (anti-HIV, IC50=1.7 microM; cytotoxicity, IC50=87 microM).

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