2. Academic Validation
  3. Targeting QseC signaling and virulence for antibiotic development

Targeting QseC signaling and virulence for antibiotic development

  • Science. 2008 Aug 22;321(5892):1078-80. doi: 10.1126/science.1160354.
David A Rasko 1,  Cristiano G Moreira,  De Run Li,  Nicola C Reading,  Jennifer M Ritchie,  Matthew K Waldor,  Noelle Williams,  Ron Taussig,  Shuguang Wei,  Michael Roth,  David T Hughes,  Jason F Huntley,  Maggy W Fina,  John R Falck,  Vanessa Sperandio
Affiliations

Affiliation

  • 1 Department of Microbiology, University of Texas (UT) Southwestern Medical Center, Dallas, TX 75390, USA.
PMID: 18719281 DOI: 10.1126/science.1160354
Abstract

Many Bacterial pathogens rely on a conserved membrane histidine sensor kinase, QseC, to respond to host adrenergic signaling molecules and Bacterial signals in order to promote the expression of virulence factors. Using a high-throughput screen, we identified a small molecule, LED209, that inhibits the binding of signals to QseC, preventing its autophosphorylation and consequently inhibiting QseC-mediated activation of virulence gene expression. LED209 is not toxic and does not inhibit pathogen growth; however, this compound markedly inhibits the virulence of several pathogens in vitro and in vivo in Animals. Inhibition of signaling offers a strategy for the development of broad-spectrum antimicrobial drugs.

Figures
Products
  • Cat. No.
    Product Name
    Description
    Target
    Research Area
  • HY-19748
    98.87%, 细菌QseC抑制剂
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