2. Academic Validation
  3. The urinary antibiotic 5-nitro-8-hydroxyquinoline (Nitroxoline) reduces the formation and induces the dispersal of Pseudomonas aeruginosa biofilms by chelation of iron and zinc

The urinary antibiotic 5-nitro-8-hydroxyquinoline (Nitroxoline) reduces the formation and induces the dispersal of Pseudomonas aeruginosa biofilms by chelation of iron and zinc

  • Antimicrob Agents Chemother. 2012 Nov;56(11):6021-5. doi: 10.1128/AAC.01484-12.
A Sobke 1,  M Klinger,  B Hermann,  S Sachse,  S Nietzsche,  O Makarewicz,  P M Keller,  W Pfister,  E Straube
Affiliations

Affiliation

  • 1 Institute of Medical Microbiology, Jena University Hospital, Jena, Germany. astrid.sobke@gmx.de
PMID: 22926564 DOI: 10.1128/AAC.01484-12
Abstract

Since cations have been reported as essential regulators of biofilm, we investigated the potential of the broad-spectrum antimicrobial and cation-chelator nitroxoline as an antibiofilm agent. Biofilm mass synthesis was reduced by up to 80% at sub-MIC nitroxoline concentrations in Pseudomonas aeruginosa, and structures formed were reticulate rather than compact. In preformed biofilms, viable cell counts were reduced by 4 logs at therapeutic concentrations. Complexation of iron and zinc was demonstrated to underlie nitroxoline's potent antibiofilm activity.

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