2. Academic Validation
  3. Tripartin, a histone demethylase inhibitor from a bacterium associated with a dung beetle larva

Tripartin, a histone demethylase inhibitor from a bacterium associated with a dung beetle larva

  • Org Lett. 2013 Apr 19;15(8):1834-7. doi: 10.1021/ol4004417.
Seong-Hwan Kim 1,  So Hee Kwon,  Seon-Hui Park,  Jae Kyun Lee,  Hea-Son Bang,  Sang-Jip Nam,  Hak Cheol Kwon,  Jongheon Shin,  Dong-Chan Oh
Affiliations

Affiliation

  • 1 Natural Products Research Institute, College of Pharmacy, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Republic of Korea.
PMID: 23550720 DOI: 10.1021/ol4004417
Abstract

Tripartin (1), a new dichlorinated indanone, was isolated from the culture broth of the Streptomyces sp. associated with a larva of the dung beetle Copris tripartitus Waterhouse. The planar structure of tripartin (1) was identified by the spectroscopic analyses of NMR, mass, UV, and IR data. The structure was confirmed, and the absolute configuration of 1 was determined by X-ray crystallography. Tripartin displayed specific activity as an inhibitor of the histone H3 lysine 9 demethylase KDM4 in HeLa cells.

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