2. Academic Validation
  3. The two faces of receptor interacting protein kinase-1

The two faces of receptor interacting protein kinase-1

  • Mol Cell. 2014 Nov 20;56(4):469-80. doi: 10.1016/j.molcel.2014.11.001.
Ricardo Weinlich 1,  Douglas R Green 2
Affiliations

Affiliations

  • 1 Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
  • 2 Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA. Electronic address: douglas.green@stjude.org.
PMID: 25459879 DOI: 10.1016/j.molcel.2014.11.001
Abstract

Receptor Interacting Protein Kinase-1 (RIPK1), a key player in inflammation and cell death, assumes opposite functions depending on the cellular context and its posttranslational modifications. Genetic evidence supported by biochemical and cellular biology approaches sheds LIGHT on the circumstances in which RIPK1 promotes or inhibits these processes.

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