2. Academic Validation
  3. Nitrogen-containing bibenzyls from Pleione bulbocodioides: absolute configurations and biological activities

Nitrogen-containing bibenzyls from Pleione bulbocodioides: absolute configurations and biological activities

  • Fitoterapia. 2015 Apr:102:120-6. doi: 10.1016/j.fitote.2015.01.015.
Yuan Li 1,  Fan Zhang 1,  Ze-Hong Wu 1,  Ke-Wu Zeng 1,  Chen Zhang 1,  Hong-Wei Jin 1,  Ming-Bo Zhao 1,  Yong Jiang 1,  Jun Li 2,  Peng-Fei Tu 3
Affiliations

Affiliations

  • 1 State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
  • 2 State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China. Electronic address: lijun@bjmu.edu.cn.
  • 3 State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China. Electronic address: pengfeitu@vip.163.com.
PMID: 25647325 DOI: 10.1016/j.fitote.2015.01.015
Abstract

Four new pyrrolidone substituted bibenzyls, dusuanlansins A-D (1-4) were isolated from the pseudo bulbs of Pleione bulbocodioides, along with 19 known compounds (5-23). Compounds 1-4 are two pairs of epimers of pyrrolidone substituted bibenzyls, which were separated successfully by a Chiralcel OD-RH C18 column. Their absolute configurations were elucidated by calculated ECD. Biological investigations showed that compounds 5 and 7 exhibited potent anti-inflammatory activities on LPS-stimulated NO production in BV-2 microglial cells, with IC50 values of 2.46 and 3.14μM, respectively.

Keywords

Anti-inflammatory activity; Bibenzyl; ECD; Epimer; Pleione bulbocodioides.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z