2. Academic Validation
  3. Fraxin Prevents Chemically Induced Hepatotoxicity by Reducing Oxidative Stress

Fraxin Prevents Chemically Induced Hepatotoxicity by Reducing Oxidative Stress

  • Molecules. 2017 Apr 6;22(4):587. doi: 10.3390/molecules22040587.
Bo Yoon Chang 1,  Young Suk Jung 2,  Chi-Su Yoon 3,  Jun Seok Oh 4,  Jae Heoi Hong 5,  Youn-Chul Kim 6,  Sung Yeon Kim 7
Affiliations

Affiliations

  • 1 Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, Iksan, Jeonbuk 54538, Korea. oama611@nate.com.
  • 2 College of Pharmacy, Pusan National University, San 30, Jangjeon-dong, Busan 46241, Korea. youngjung@pusan.ac.kr.
  • 3 Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, Iksan, Jeonbuk 54538, Korea. ycs1991@naver.com.
  • 4 Dongbu Eastern Herbal Medicine Agricultural Association Corporation, Yeosunro 1679, Sunchun-si, Jeonnam 58019, Korea. 5811684@daum.net.
  • 5 Dongbu Eastern Herbal Medicine Agricultural Association Corporation, Yeosunro 1679, Sunchun-si, Jeonnam 58019, Korea. 5811684@naver.com.
  • 6 Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, Iksan, Jeonbuk 54538, Korea. wku114@naver.com.
  • 7 Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, Iksan, Jeonbuk 54538, Korea. sungykim@wonkwang.ac.kr.
PMID: 28383514 DOI: 10.3390/molecules22040587
Abstract

Fraxin isolated from Acer tegmentosum is reported to exert potent anti-oxidative stress action. However, pharmacological activities of fraxin remain to be elucidated. This study investigated the potential hepatoprotective effects of fraxin and the underlying signaling mechanism involved. Treatment with fraxin significantly lowered the serum levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in a CCl₄-induced hepatotoxicity rat model. In the fraxin-treated group, glutathione (GSH) significantly increased, while the malondialdehyde (MDA) in the liver significantly decreased. Fraxin also showed radical-scavenging activity. Furthermore, it significantly reduced the t-BHP-induced cytotoxicity and production of Reactive Oxygen Species (ROS) in Hep G2. Fraxin protected Hep G2 cells through Nrf2 pathway-dependent HO-1 expression. The results of this study indicate that fraxin shows potent hepatoprotective effects in vitro and in vivo, presumably through direct antioxidant activity and the Nrf2-mediated antioxidant Enzyme system.

Keywords

A. tegmentosum; HO-1; Nrf2; antioxidant; fraxin; hepatoprotective.

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