1. Academic Validation
  2. DNA sequencing at 40: past, present and future

DNA sequencing at 40: past, present and future

  • Nature. 2017 Oct 19;550(7676):345-353. doi: 10.1038/nature24286.
Jay Shendure 1 2 Shankar Balasubramanian 3 4 George M Church 5 Walter Gilbert 6 Jane Rogers 7 Jeffery A Schloss 8 Robert H Waterston 1
Affiliations

Affiliations

  • 1 Department of Genome Sciences, University of Washington, Seattle, Washington, USA.
  • 2 Howard Hughes Medical Institute, Seattle, Washington, USA.
  • 3 Department of Chemistry, University of Cambridge, Cambridge, UK.
  • 4 Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.
  • 5 The Wyss Institute & Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA.
  • 6 Department of Molecular and Cellular Biology, Harvard University, Cambridge Massachusetts, USA.
  • 7 International Wheat Genome Sequencing Consortium, Little Eversden, Cambridge, UK.
  • 8 National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.
Abstract

This review commemorates the 40th anniversary of DNA Sequencing, a period in which we have already witnessed multiple technological revolutions and a growth in scale from a few kilobases to the first human genome, and now to millions of human and a myriad of other genomes. DNA Sequencing has been extensively and creatively repurposed, including as a 'counter' for a vast range of molecular phenomena. We predict that in the long view of history, the impact of DNA Sequencing will be on a par with that of the microscope.

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