2. Academic Validation
  3. Quellenin, a new anti-Saprolegnia compound isolated from the deep-sea fungus, Aspergillus sp. YK-76

Quellenin, a new anti-Saprolegnia compound isolated from the deep-sea fungus, Aspergillus sp. YK-76

  • J Antibiot (Tokyo). 2018 Aug;71(8):741-744. doi: 10.1038/s41429-018-0053-z.
Konami Takahashi 1 2 3,  Kazunari Sakai 3,  Wataru Fukasawa 4,  Yuriko Nagano 2,  Sakiko Orui Sakaguchi 2,  Andre O Lima 5,  Vivian H Pellizari 6,  Masato Iwatsuki 3 4,  Kiyotaka Takishita 2,  Takao Yoshida 2,  Kenichi Nonaka 7 8,  Katsunori Fujikura 2,  Satoshi Ōmura 9
Affiliations

Affiliations

  • 1 Graduate School of Marine Science and Technology, Tokyo University of Marine Science and Technology, Tokyo, Japan.
  • 2 Japan Agency for Marine-Earth Science and Technology (JAMSTEC), Kanagawa, Japan.
  • 3 Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan.
  • 4 Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan.
  • 5 Department of Biological Sciences, University of Vale do Itajaí, CTTMar, R. Uruguai, 458-CEP, 88302-202, Itajaí, Brazil.
  • 6 Institute of Oceanography, University of São Paulo, 191. Praca do Oceanografico, São Paulo, 05508120, Brazil.
  • 7 Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan. ken@lisci.kitasato-u.ac.jp.
  • 8 Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan. ken@lisci.kitasato-u.ac.jp.
  • 9 Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan. omuras@insti.kitasato-u.ac.jp.
PMID: 29686353 DOI: 10.1038/s41429-018-0053-z
Abstract

Saprolegnia parasitica, belonging to oomycetes, is one of virulent pathogen of fishes such as salmon and trout, and causes tremendous damage and losses in commercial aquacultures by saprolegniasis. Previously, malachite green, an effective medicine, had been used to control saprolegniasis. However, this drug has been banned around the world due to its mutagenicity. Therefore, novel anti-saprolegniasis compounds are urgently needed. As a new frontier to discover bioactive compounds, we focused on the deep-sea fungi for the isolation of anti-saprolegniasis compounds. In this paper, on the course of anti-saprolegniasis agents from 546 cultured broths of 91 deep-sea Fungal strains, we report a new compound, named quellenin (1) together with three known compounds, diorcinol (2), violaceol-I (3) and violaceol-II (4), from deep-sea fungus Aspergillus sp. YK-76. This strain was isolated from an Osedax sp. annelid, commonly called bone-eating worm, collected at the São Paulo Ridge in off Brazil. Compounds 2, 3 and 4 showed anti-S. parasitica activity. Our results suggest that diorcinol and violaceol analogs and could be good lead candidates for the development of novel agents to prevent saprolegniasis.

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