2. Academic Validation
  3. Long non-coding RNA LINC00222 regulates GSK3β activity and promotes cell apoptosis in lung adenocarcinoma

Long non-coding RNA LINC00222 regulates GSK3β activity and promotes cell apoptosis in lung adenocarcinoma

  • Biomed Pharmacother. 2018 Oct;106:755-762. doi: 10.1016/j.biopha.2018.06.165.
Hongyan Zhang 1,  Yuan Wang 2,  Jibin Lu 3,  Yanyan Zhao 4
Affiliations

Affiliations

  • 1 Department of Clinical Genetics, Shengjing Hospital of China Medical University, No.36 San Hao Street, Shenyang, 110004, PR China; Department of Thoracic surgery, Shengjing Hospital of China Medical University, No.36 San Hao Street, Shenyang, 110004, PR China.
  • 2 Department of Rehabilitation, Shengjing Hospital of China Medical University, No.36 San Hao Street, Shenyang, 110004, PR China.
  • 3 Department of Thoracic surgery, Shengjing Hospital of China Medical University, No.36 San Hao Street, Shenyang, 110004, PR China.
  • 4 Department of Clinical Genetics, Shengjing Hospital of China Medical University, No.36 San Hao Street, Shenyang, 110004, PR China. Electronic address: yyzhao@sj-hospital.org.
PMID: 29990868 DOI: 10.1016/j.biopha.2018.06.165
Abstract

Recent evidence indicates that long noncoding RNAs (lncRNAs) play a critical role in the regulating cellular processes such as differentiation, proliferation, metastasis and Apoptosis. These lncRNAs are found to be dysregulated in a variety of cancers. However, the underlying mechanisms of lncRNAs action in lung adenocarcinoma remain unclear. We investigated expression of the lncRNA LINC00222 in 76 lung adenocarcinoma tissues and paired normal lung tissues and found that LINC00222 is downregulated in lung adenocarcinoma tissues. Enforced expression of LINC00222 significantly inhibited the proliferation, migration and invasive ability of lung adenocarcinoma cells, and also induced Apoptosis. Furthermore, overexpression of LINC00222 enhanced the activity of glycogen synthase kinase-3β (GSK3β), which is a key element of the Wnt signaling pathway. Taken together, our findings suggest that LINC00222 acts as a tumor suppressor in lung adenocarcinoma and, therefore, could serve as a valuable prognostic biomarker and therapeutic target for lung adenocarcinoma patients.

Keywords

GSK3β; LINC00222; Lung cancer; Wnt signaling pathway.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z