[Chemical Constituents of Alkaloids from the Bark of Sophora japonica]

Objective: To study the chemical constituents in the bark of Sophora japonica.

Methods: The chemical constituents were separated and purified by silica gel,Sephadex LH-20 column chromatography,and HPLC. Their structures were identified by various spectroscopic analyses.

Results: Eleven compounds were obtained from the bark of Sophora japonica. Their structures were identified as( +)-oxymatrine( 1),isosophoridine( 2),lupanine( 3),( +)-matrine( 4),( +)-sophoramine( 5),(-)-14β-hydroxymatrine( 6),(-)-7,11-dehydromatrine( 7),alopecurin A( 8),( +)-sophoranol( 9),α-isolupanine( 10) and( +)-allomatrine( 11).

Conclusion: Compounds 2,3,5 and 7 ~ 11 are isolated from this plant for the first time.