2. Academic Validation
  3. β-Amyrin Ameliorates Alzheimer's Disease-Like Aberrant Synaptic Plasticity in the Mouse Hippocampus

β-Amyrin Ameliorates Alzheimer's Disease-Like Aberrant Synaptic Plasticity in the Mouse Hippocampus

  • Biomol Ther (Seoul). 2020 Jan 1;28(1):74-82. doi: 10.4062/biomolther.2019.024.
Hye Jin Park 1,  Huiyoung Kwon 1,  Ji Hye Lee 2,  Eunbi Cho 1,  Young Choon Lee 1 3,  Minho Moon 4,  Mira Jun 3 5,  Dong Hyun Kim 1 3,  Ji Wook Jung 6
Affiliations

Affiliations

  • 1 Department of Medicinal Biotechnology, College of Health Sciences, Dong-A University, Busan 49315, Republic of Korea.
  • 2 Division of Endocrinology, School of Medicine, Kyungpook National University, Daegu 41944, Republic of Korea.
  • 3 Institute of Convergence Bio-Health, Dong-A University, Busan 49315, Republic of Korea.
  • 4 Department of Biochemistry, College of Medicine, Konyang University, Daejeon 35365, Republic of Korea.
  • 5 Department of Food Science and Nutrition, College of Health Sciences, Dong-A University, Busan 49315, Republic of Korea.
  • 6 Department of Herbal Medicinal Pharmacology, College of Herbal Bio-industry, Daegu Haany University, Kyungsan 38610, Republic of Korea.
PMID: 31357749 DOI: 10.4062/biomolther.2019.024
Abstract

Alzheimer's disease (AD) is a progressive and most frequently diagnosed neurodegenerative disorder. However, there is still no drug preventing the progress of this disorder. β-Amyrin, an ingredient of the surface wax of tomato fruit and dandelion coffee, is previously reported to ameliorate memory impairment induced by cholinergic dysfunction. Therefore, we tested whether β-amyrin can prevent AD-like pathology. β-Amyrin blocked amyloid β (Aβ)-induced long-term potentiation (LTP) impairment in the hippocampal slices. Moreover, β-amyrin improved Aβ-induced suppression of phosphatidylinositol-3-kinase (PI3K)/Akt signaling. LY294002, a PI3K Inhibitor, blocked the effect of β-amyrin on Aβ-induced LTP impairment. In in vivo experiments, we observed that β-amyrin ameliorated object recognition memory deficit in Aβ-injected AD mice model. Moreover, neurogenesis impairments induced by Aβ was improved by β-amyrin treatment. Taken together, β-amyrin might be a good candidate of treatment or supplement for AD patients.

Keywords

Alzheimer's disease; Amyloid β; Synaptic plasticity; β-amyrin.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z