2. Academic Validation
  3. G6PD deficiency: An update

G6PD deficiency: An update

  • JAAPA. 2019 Nov;32(11):21-26. doi: 10.1097/01.JAA.0000586304.65429.a7.
Susan J Harcke 1,  Denise Rizzolo,  H Theodore Harcke
Affiliations

Affiliation

  • 1 Susan J. Harcke is a PA and medical officer in the Delaware National Guard's 31st Civil Support Team in Smyrna, Del. Denise Rizzolo is an assistant clinical professor at the Pace Completion Program in the Department of Physician Studies in New York City and an assessment specialist for the Physician Assistant Education Association. H. Theodore Harcke is a professor of radiology and pediatrics at Sidney Kimmel College of Medicine, Thomas Jefferson University, in Philadelphia, Pa. The authors have disclosed no potential conflicts of interest, financial or otherwise.
PMID: 31609781 DOI: 10.1097/01.JAA.0000586304.65429.a7
Abstract

Although glucose-6-phosphate dehydrogenase (G6PD) deficiency is less known in Western countries than in the Middle East and Africa, global migration and immigration are bringing ethnic groups with the highest incidence of this inherited genetic disorder into the US healthcare system. The G6PD Enzyme is critical to protecting erythrocytes against oxidative stress, and deficiency may lead to hemolysis in the presence of certain environmental factors such as Infection and some medications and foods. Neonatal jaundice, favism, and hemolysis are associated with exposure to increased oxidative stressors in patients with G6PD deficiency. By recognizing the potential for G6PD deficiency, clinicians can screen for the disorder and teach affected patients how to avoid triggers that result in harmful clinical manifestations.

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