Discovery of a NAPE-PLD inhibitor that modulates emotional behavior in mice

Affiliations

• 1 Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Leiden, the Netherlands.
• 2 Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA.
• 3 Laboratory of Behavioral and Genomic Neuroscience, National Institute on Alcoholism and Alcohol Abuse (NIAAA), National Institute of Health (NIH), Bethesda, MD, USA.
• 4 Laboratory of Physiologic Studies, NIAAA, NIH, Bethesda, MD, USA.
• 5 Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.
• 6 Analytical Biosciences and Metabolomics, Division of Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands.
• 7 Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA, USA.
• 8 Laboratory of Cardiovascular Physiology and Tissue Injury, NIAAA, NIH, Bethesda, MD, USA.
• 9 School of Neuroscience, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA.
• 10 Oncode Institute, Leiden, the Netherlands.
• 11 Bio-organic Synthesis, Leiden Institute of Chemistry, Leiden University, Leiden, the Netherlands.
• 12 Pivot Park Screening Centre B.V., Oss, the Netherlands.
• 13 Roche Innovation Center Basel, F. Hoffman-La Roche Ltd, Basel, Switzerland.
• 14 Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, VA, USA.
• 15 Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Leiden, the Netherlands. m.van.der.stelt@chem.leidenuniv.nl.
• 16 Oncode Institute, Leiden, the Netherlands. m.van.der.stelt@chem.leidenuniv.nl.