2. Academic Validation
  3. Recommended tool compounds and drugs for blocking P2X and P2Y receptors

Recommended tool compounds and drugs for blocking P2X and P2Y receptors

  • Purinergic Signal. 2021 Dec;17(4):633-648. doi: 10.1007/s11302-021-09813-7.
Christa E Müller 1,  Vigneshwaran Namasivayam 2
Affiliations

Affiliations

  • 1 PharmaCenter Bonn, Pharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, An der Immenburg 4, 53121, Bonn, Germany. christa.mueller@uni-bonn.de.
  • 2 PharmaCenter Bonn, Pharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, An der Immenburg 4, 53121, Bonn, Germany.
PMID: 34476721 DOI: 10.1007/s11302-021-09813-7
Abstract

This review article presents a collection of tool compounds that selectively block and are recommended for studying P2Y and P2X Receptor subtypes, investigating their roles in physiology and validating them as future drug targets. Moreover, drug candidates and approved drugs for P2 receptors will be discussed.

Keywords

Agonist; Antagonist; Drug; Gefapixant; P2X receptor; P2Y receptor.

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