2. Academic Validation
  3. Synergistic chemo-photothermal cancer therapy of pH-responsive polymeric nanoparticles loaded IR825 and DTX with charge-reversal property

Synergistic chemo-photothermal cancer therapy of pH-responsive polymeric nanoparticles loaded IR825 and DTX with charge-reversal property

  • Colloids Surf B Biointerfaces. 2022 Jan;209(Pt 2):112164. doi: 10.1016/j.colsurfb.2021.112164.
Xiaowei Wang 1,  Yaxuan Gu 2,  Qi Li 3,  Yapeng Xu 1,  Yifan Shi 1,  Zheran Wang 4,  Mingyu Xia 3,  Ji Li 2,  Dongkai Wang 5
Affiliations

Affiliations

  • 1 Department of Pharmaceutics, Shenyang Pharmaceutical University, No.103, Wenhua Road, Shenyang, China.
  • 2 Department of Traditional Chinese Medicine, Shenyang Pharmaceutical University, No.103, Wenhua Road, Shenyang 110016, China.
  • 3 Department of Pharmacology, Shenyang Pharmaceutical University, No.103, Wenhua Road, Shenyang 110016, China.
  • 4 Department of Mathematics and Statistics. College of Sciences and Mathematics. Auburn University, 221Parker Hall, Auburn, AL 36849, USA.
  • 5 Department of Pharmaceutics, Shenyang Pharmaceutical University, No.103, Wenhua Road, Shenyang, China. Electronic address: wangycsyphu@126.com.
PMID: 34735859 DOI: 10.1016/j.colsurfb.2021.112164
Abstract

IR825 is a kind of near-infrared (NIR) small molecule cyanine dye and has distinct near-infrared absorbance and excellent thermal conversion performance. Due to poor stability and insufficient therapy efficacy, various nano-systems have been developed as delivery vehicles for NIR dyes to improve their application in tumor treatment. Herein, we developed an intelligent polymer drug vehicle (Mal-PAH-PEG-DMMA/ poly (ethylene imine) - poly(ε-caprolactone) block Polymers, MPPD/PEI-PCL) based on pH-responsive charge-reversal to deliver docetaxel (DTX) and photosensitizer (IR825) for chemo-photothermal combination therapy (MPPD@IR825/DTX NPs). MPPD@IR825/DTX NPs could undergo charge conversion in a slightly acidic microenvironment (pH 6.8), resulted in strong electrostatic repulsion to withdraw the shell of the polymer nanoparticles (MPPD), enhanced cellular uptake and increased drug release. MPPD@IR825/DTX NPs demonstrated nanoscale in size with good mono-dispersity and stability, triggered DTX release in response to acid environment and NIR stimulation, in the same time providing excellent photothermal conversion efficiency. In vitro and In vivo experiments confirmed that charge-reversal polymeric nanoparticles improved antitumor efficiency in 4T1 tumor cell modal than non-charge-reversal polymeric nanoparticles. Furthermore, in comparison with chemotherapy or photothermal therapy in a single treatment mode, chemo-photothermal combination therapy of MPPD@IR825/DTX NPs with laser irradiation showed highly efficient tumor ablation. In addition, the polymeric nanoparticles exhibited good biocompatibility and safety. Therefore, the design of charge-reversal polymeric nanoparticles (MPPD@IR825/DTX NPs) provides a new strategy and promising application for targeting and synergistic chemo-photothermal combination therapy.

Keywords

Charge-reversal; Chemo-photothermal therapy; Synergistic therapy; pH-responsive.

Figures
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  • HY-118924
    98.27%, 荧光染料
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