2. Academic Validation
  3. Netzahualcoyonol from Salacia multiflora (Lam.) DC. (Celastraceae) roots as a bioactive compound against gram-positive pathogens

Netzahualcoyonol from Salacia multiflora (Lam.) DC. (Celastraceae) roots as a bioactive compound against gram-positive pathogens

  • Nat Prod Res. 2022 Nov;36(22):5904-5909. doi: 10.1080/14786419.2021.2023865.
Waleska Stephanie da Cruz Nizer 1 2,  Ariane Coelho Ferraz 3,  Thaís de Fátima Silva Moraes 4,  William Gustavo Lima 5,  Josana Pereira Dos Santos 6,  Lucienir Pains Duarte 6,  Cintia Lopes de Brito Magalhães 3,  Sidney Augusto Vieira-Filho 7,  José Carlos de Magalhães 1
Affiliations

Affiliations

  • 1 Department of Chemistry, Biotechnology, and Bioprocess Engineering, Universidade Federal de São João del-Rei, Ouro Branco, MG, Brazil.
  • 2 Carleton University, Ottawa, ON, Canada.
  • 3 Institute of Exact and Biological Sciences, Biological Science Research Nucleus, Universidade Federal de Ouro Preto, Ouro Preto, MG, Brazil.
  • 4 Department of Microbiology, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
  • 5 Laboratory of Medical Microbiology, Campus Centro Oeste Dona Lindu, Universidade Federal de São João del-Rei, Divinópolis, MG, Brazil.
  • 6 Department of Chemistry, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
  • 7 Department of Pharmacy, Universidade Federal de Ouro Preto, Ouro Preto, MG, Brazil.
PMID: 34994265 DOI: 10.1080/14786419.2021.2023865
Abstract

The expression of virulence factors, such as biofilm formation, in association with the acquisition of resistance to multiple drugs, has evidenced the need for new and effective antimicrobial agents against Staphylococcus aureus. The evaluation of the pharmacological properties of plant-derived compounds is a promising alternative to the development of new antimicrobials. In this study, we aimed to evaluate the Antibacterial, antibiofilm, and the synergistic and cytotoxic effects of netzahualcoyonol isolated from Salacia multiflora (Lam.) DC. roots. Netzahualcoyonol presented bacteriostatic (1.56-25.0 µg/mL) and bactericidal (25.0-400.0 µg/mL) effects against Gram-positive bacteria, disrupted the biofilm of S. aureus, and presented a synergistic effect after its combination with β-lactams and aminoglycosides. The low cytotoxicity of netzahualcoyonol (Selectivity Index (SI) for S. aureus (2.56), S. saprophyticus (20.56), and Bacillus subtilis (1.28)) suggests a good security profile. Taken together, these results show that netzahualcoyonol is promising for the development of a new effective Antibacterial agent.

Keywords

Celastraceae; Netzahualcoyonol; Salacia multiflora (Lam.) DC.; antibacterial; antibiofilm; gram-positive; synergism.

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