2. Academic Validation
  3. The flavonoid corylin exhibits lifespan extension properties in mouse

The flavonoid corylin exhibits lifespan extension properties in mouse

  • Nat Commun. 2022 Mar 9;13(1):1238. doi: 10.1038/s41467-022-28908-2.
Tong-Hong Wang  # 1 2,  Wei-Che Tseng  # 3,  Yann-Lii Leu  # 1 3,  Chi-Yuan Chen 1 2,  Wen-Chih Lee 4,  Ying-Chih Chi 5,  Shu-Fang Cheng 3,  Chun-Yu Lai 3,  Chen-Hsin Kuo 3,  Shu-Ling Yang 6,  Sien-Hung Yang 6 7,  Jiann-Jong Shen 6,  Chun-Hao Feng 3,  Chih-Ching Wu 8 9 10 11,  Tsong-Long Hwang 2 3 12,  Chia-Jen Wang 13,  Shu-Huei Wang 14,  Chin-Chuan Chen 15 16
Affiliations

Affiliations

  • 1 Tissue Bank, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
  • 2 Graduate Institute of Health Industry Technology, Research Center for Food and Cosmetic Safety, Research Center for Chinese Herbal Medicine, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan.
  • 3 Graduate Institute of Natural Products, Chang Gung University, Taoyuan, Taiwan.
  • 4 Office of Research and Development, Tzu Chi University, Hualien, Taiwan.
  • 5 Cryo-EM Center, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, USA.
  • 6 School of Traditional Chinese Medicine, Chang Gung University, Taoyuan, Taiwan.
  • 7 Division of Chinese Internal Medicine, Center for Traditional Chinese Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
  • 8 Department of Medical Biotechnology and Laboratory Science, Chang Gung University, Taoyuan, Taiwan.
  • 9 Department of Otolaryngology-Head & Neck Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
  • 10 Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan.
  • 11 Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
  • 12 Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
  • 13 Cell Therapy Core Laboratory, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
  • 14 Department of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taipei, Taiwan. shwang@ntu.edu.tw.
  • 15 Tissue Bank, Chang Gung Memorial Hospital, Taoyuan, Taiwan. chinchuan@mail.cgu.edu.tw.
  • 16 Graduate Institute of Natural Products, Chang Gung University, Taoyuan, Taiwan. chinchuan@mail.cgu.edu.tw.
  • # Contributed equally.
PMID: 35264584 DOI: 10.1038/s41467-022-28908-2
Abstract

In the long history of traditional Chinese medicine, single herbs and complex formulas have been suggested to increase lifespan. However, the identification of single molecules responsible for lifespan extension has been challenging. Here, we collected a list of traditional Chinese medicines with potential longevity properties from pharmacopeias. By utilizing the mother enrichment program, we systematically screened these traditional Chinese medicines and identified a single herb, Psoralea corylifolia, that increases lifespan in Saccharomyces cerevisiae. Next, twenty-two pure compounds were isolated from Psoralea corylifolia. One of the compounds, corylin, was found to extend the replicative lifespan in yeast by targeting the Gtr1 protein. In human umbilical vein endothelial cells, RNA Sequencing data showed that corylin ameliorates cellular senescence. We also examined an in vivo mammalian model, and found that corylin extends lifespan in mice fed a high-fat diet. Taken together, these findings suggest that corylin may promote longevity.

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