2. Academic Validation
  3. Biological effects of acetomycin. I. Activity against tumor cells in vitro and in vivo

Biological effects of acetomycin. I. Activity against tumor cells in vitro and in vivo

  • J Antibiot (Tokyo). 1987 Jan;40(1):73-6. doi: 10.7164/antibiotics.40.73.
S W Mamber,  J D Mitulski,  K L Hamelehle,  J C French,  G C Hokanson,  J L Shillis,  W R Leopold,  D D Von Hoff,  J B Tunac
PMID: 3558118 DOI: 10.7164/antibiotics.40.73
Abstract

The Antibiotic acetomycin was active in vitro against HCT-8 human colon adenocarcinoma cells (IC50, 1.5 microgram/ml) and L1210 murine leukemia cells (IC50, 2.2 micrograms/ml). Acetomycin also had marked activity in the human tumor stem cell assay, with a 33% overall response rate (less than or equal to 30% survival) against 49 primary tumors. However, acetomycin was inactive in four in vivo tumor assay systems (L1210 and P388 leukemias, B16 melanoma and the MX-1 mammary xenograft system). This lack of in vivo activity may result from metabolic inactivation of acetomycin.

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