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  3. Porcn as a novel therapeutic target in cancer therapy: A review

Porcn as a novel therapeutic target in cancer therapy: A review

  • Cell Biol Int. 2022 Dec;46(12):1979-1991. doi: 10.1002/cbin.11882.
Mortaza Raeisi 1,  Maryam Saberivand 1,  Kobra Velaei 2,  Negar Aghaei 3 4,  Nasim Rahimi-Farsi 5,  Hengameh Kharrati-Shishavan 6,  Davoud Hassanzadeh 7,  Amir Mehdizadeh 1
Affiliations

Affiliations

  • 1 Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
  • 2 Department of Anatomical Sciences, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
  • 3 Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
  • 4 Imam Sajjad Hospital, Tabriz, Iran.
  • 5 Department of Biology, University College of Nabi Akram, Tabriz, Iran.
  • 6 Department of Plant Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran.
  • 7 Department of Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran.
PMID: 35971741 DOI: 10.1002/cbin.11882
Abstract

Wingless-related integration site (Wnt) signaling is one of the main oncogenic pathways in different malignancies. Therefore, targeting this pathway has been considered an exciting strategy in Cancer treatment. Porcn is among the central Enzymes in this pathway that has recently been considered for cancer-targeted therapy. As a membrane-bound O-acyltransferase, Porcn plays a critical role in Wnt ligand palmitoylation and its subsequent secretion. In addition to Porcn's role in stem cell signaling and differentiation, recent findings have shown its role in developing and progressing colorectal, pancreatic, liver, head, and neck cancers. Developed small molecule inhibitors have also opened a promising window toward Cancer treatment strategies. In this review, the structure and biological role of Porcn in different cancer-related signaling pathways and inhibitors used for inhibiting this Enzyme are discussed.

Keywords

cancer; cell migration; lipid mediators; metastasis; tumor suppressor.

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