2. Academic Validation
  3. PIM2 Promotes the Development of Ovarian Endometriosis by Enhancing Glycolysis and Fibrosis

PIM2 Promotes the Development of Ovarian Endometriosis by Enhancing Glycolysis and Fibrosis

  • Reprod Sci. 2023 Apr 14. doi: 10.1007/s43032-023-01208-w.
Mengxue Wang # 1 2,  Ruiqi Fan # 1 2,  Junyi Jiang # 1,  Fangyuan Sun 1 2,  Yujun Sun 1 2,  Qian Wang 1 2,  Aifang Jiang 1,  Zhenhai Yu 3,  Tingting Yang 4
Affiliations

Affiliations

  • 1 Department of Reproductive Medicine, Affiliated Hospital of Weifang Medical University, Weifang, Shandong Province, People's Republic of China.
  • 2 School of Clinical Medicine, Weifang Medical University, Weifang, Shandong Province, People's Republic of China.
  • 3 Department of Reproductive Medicine, Affiliated Hospital of Weifang Medical University, Weifang, Shandong Province, People's Republic of China. tomsyu@163.com.
  • 4 Department of Reproductive Medicine, Affiliated Hospital of Weifang Medical University, Weifang, Shandong Province, People's Republic of China. Y402115432@163.com.
  • # Contributed equally.
PMID: 37059967 DOI: 10.1007/s43032-023-01208-w
Abstract

Endometriosis is a common gynecological disorder characterized by the presence of the endometrial glands and the stroma outside the uterine cavity. The disease affects reproductive function and quality of life in women of reproductive age. Endometriosis is similar to tumors in some characteristics, such as glycolysis. PIM2 can promote the development of tumors, but the mechanism of PIM2 in endometriosis is still unclear. Therefore, our goal is to study the mechanism of PIM2 in endometriosis. Through immunohistochemistry, we found PIM2, HK2, PKM2, SMH (smooth muscle Myosin heavy chain), Desmin, and α-SMA (α-smooth muscle actin) were strongly expressed in the ovarian endometriosis. In endometriotic cells, PIM2 enhanced glycolysis and fibrosis via upregulating the expression of PKM2. Moreover, the PIM2 Inhibitor SMI-4a inhibited the development of endometriosis. And we established a PIM2 knockout mouse model of endometriosis to demonstrate the role of PIM2 in vivo. In summary, our study indicates that PIM2 promotes the development of endometriosis. PIM2 may serve as a promising therapeutic target for endometriosis.

Keywords

Endometriosis; Fibrosis; Glycolysis; PIM2; PKM2.

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