2. Academic Validation
  3. [68Ga]Ga-FAPI-46 synthesis on a GAIA® module system: Thorough study of the automated radiolabeling reaction conditions

[68Ga]Ga-FAPI-46 synthesis on a GAIA® module system: Thorough study of the automated radiolabeling reaction conditions

  • Appl Radiat Isot. 2024 Feb 1:206:111211. doi: 10.1016/j.apradiso.2024.111211.
Léa Rubira 1,  Charlotte Donzé 1,  Juliette Fouillet 1,  Benjamin Algudo 1,  Pierre Olivier Kotzki 2,  Emmanuel Deshayes 2,  Cyril Fersing 3
Affiliations

Affiliations

  • 1 Nuclear medicine department, Institut régional du Cancer de Montpellier (ICM), Univ. Montpellier, Montpellier, France.
  • 2 Nuclear medicine department, Institut régional du Cancer de Montpellier (ICM), Univ. Montpellier, Montpellier, France; Institut de Recherche en Cancérologie de Montpellier (IRCM), INSERM U1194, Univ. Montpellier, Institut régional du Cancer de Montpellier (ICM), Montpellier, France.
  • 3 Nuclear medicine department, Institut régional du Cancer de Montpellier (ICM), Univ. Montpellier, Montpellier, France; IBMM, Univ Montpellier, CNRS, ENSCM, Montpellier, France. Electronic address: cyril.fersing@icm.unicancer.fr.
PMID: 38309117 DOI: 10.1016/j.apradiso.2024.111211
Abstract

The influence of several parameters involved in the 68Ga radiolabeling of FAPI-46 was studied at the scale of the automated reaction. Among the buffers tested, HEPES 0.3 M pH 4 allowed both high radiochemical purity (RCP) and radiochemical yield (RCY), without prepurification of 68Ga but after final purification of [68Ga]Ga-FAPI-46 on a C18 cartridge. A longer reaction time did not show significant benefit on the RCP, while higher loads of FAPI-46 and gentisic acid as anti-radiolysis compound allowed better RCY.

Keywords

Automated production; FAPI-46; Fibroblast; Gallium-68; Molecular imaging; Radiochemistry.

Figures
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  • HY-137331
    98.57%, 放射性示踪剂
    FAP
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