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  3. A smart tablet-phone-based high-performance pancreatic cancer cell biosensing system for drug screening

A smart tablet-phone-based high-performance pancreatic cancer cell biosensing system for drug screening

  • Talanta. 2024 Jun 25:278:126484. doi: 10.1016/j.talanta.2024.126484.
Qiang Wang 1,  Tao Liang 2,  Wenjian Yang 3,  Youjian Xu 1,  Chunlian Qin 4,  Haote Han 5,  Xiyang Zhou 6,  Yingwei Wang 7,  Zhen Wang 8,  Ning Hu 9
Affiliations

Affiliations

  • 1 Department of General Surgery, Tiantai People's Hospital of Zhejiang Province (Tiantai Branch of Zhejiang Provincial People's Hospital), Hangzhou Medical College, Taizhou, 317200, Zhejiang, China.
  • 2 Laboratory Medicine Center, Department of Transfusion Medicine, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, 310014, China; Department of Chemistry, Zhejiang-Israel Joint Laboratory of Self-Assembling Functional Materials, ZJU-Hangzhou Global Scientific and Technological Innovation Center, Zhejiang University, Hangzhou, 310058, China.
  • 3 Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, Zhejiang, 310024, China.
  • 4 Department of Chemistry, Zhejiang-Israel Joint Laboratory of Self-Assembling Functional Materials, ZJU-Hangzhou Global Scientific and Technological Innovation Center, Zhejiang University, Hangzhou, 310058, China.
  • 5 Department of Chemistry, Zhejiang-Israel Joint Laboratory of Self-Assembling Functional Materials, ZJU-Hangzhou Global Scientific and Technological Innovation Center, Zhejiang University, Hangzhou, 310058, China. Electronic address: haotehan@zju.edu.cn.
  • 6 Department of General Surgery, Tiantai People's Hospital of Zhejiang Province (Tiantai Branch of Zhejiang Provincial People's Hospital), Hangzhou Medical College, Taizhou, 317200, Zhejiang, China. Electronic address: zhou1xiyang@163.com.
  • 7 Department of Laboratory Medicine, Tiantai People's Hospital of Zhejiang Province (Tiantai Branch of Zhejiang Provincial People's Hospital), Hangzhou Medical College, Taizhou, 317200, Zhejiang, China. Electronic address: wyw724@163.com.
  • 8 Department of General Surgery, Tiantai People's Hospital of Zhejiang Province (Tiantai Branch of Zhejiang Provincial People's Hospital), Hangzhou Medical College, Taizhou, 317200, Zhejiang, China; Laboratory Medicine Center, Department of Transfusion Medicine, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, 310014, China. Electronic address: wangzhen@hmc.edu.cn.
  • 9 Department of Chemistry, Zhejiang-Israel Joint Laboratory of Self-Assembling Functional Materials, ZJU-Hangzhou Global Scientific and Technological Innovation Center, Zhejiang University, Hangzhou, 310058, China; General Surgery Department, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children's Health, Hangzhou, 310052, China. Electronic address: huning@zju.edu.cn.
PMID: 38941810 DOI: 10.1016/j.talanta.2024.126484
Abstract

Exploring more efficient pancreatic Cancer drug screening platforms is of significant importance for accelerating the drug development process. In this study, we developed a high-sensitivity bioluminescence system based on smartphones and smart tablets, and constructed a pancreatic Cancer drug screening platform (PCDSP) by combining the pancreatic Cancer cell sensing model (PCCSM) on the multiwell plates (MTP). A smart tablet was used as the LIGHT source and a smartphone as the colorimetric sensing device. The smartphone dynamically controls the color and brightness displayed on the smart tablet to achieve lower LOD and wider detection ranges. We constructed PCCSM for 24 h, 48 h, and 72 h , and performed colorimetric experiments using both PCDSP and a commercial plate reader (CPR). The results showed that the PCDSP had a lower LOD than that of CPR. Moreover, PCDSP even exhibited a lower LOD for 24 h PCCSM testing compared to CPR for 48 h PCCSM testing, effectively shortening the drug evaluation process. Additionally, the PCDSP offers higher portability and efficiency compared with CPR, making it a promising platform for efficient pancreatic Cancer drug screening.

Keywords

Biosensing system; Drug screening; Pancreatic cancer cell; Smart tablet-phone-based system.

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