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  3. The effect of clidanac, a potent anti-inflammatory drug, on mitochondrial respiration: a consideration on the uncoupling activity of optical enantiomers

The effect of clidanac, a potent anti-inflammatory drug, on mitochondrial respiration: a consideration on the uncoupling activity of optical enantiomers

  • Res Commun Chem Pathol Pharmacol. 1984 Sep;45(3):399-406.
K Kawai,  H Shiojiri,  H Fukushima,  Y Nozawa,  J Hasegawa,  M Nozaki,  K Tsurumi,  H Fujimura
PMID: 6334337
Abstract

The uncoupling activities of clidanac and its dechlorinated derivative on Oxidative Phosphorylation were examined using isolated rat liver mitochondria. Clidanac was found to uncouple the Oxidative Phosphorylation and no difference was detected in the uncoupling potency of the two enantiomorphs. Dechlorclidanac was significantly less effective in the uncoupling activity than clidanac.

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