2. Academic Validation
  3. A new aromatase inhibitor, FR901537. I. Taxonomy, fermentation, isolation, physiochemical characteristics and biological activities

A new aromatase inhibitor, FR901537. I. Taxonomy, fermentation, isolation, physiochemical characteristics and biological activities

  • J Antibiot (Tokyo). 1995 Aug;48(8):757-62. doi: 10.7164/antibiotics.48.757.
N Oohata 1,  Y Hori,  Y Yamagishi,  T Fujita,  S Takase,  M Yamashita,  H Terano,  M Okuhara
Affiliations

Affiliation

  • 1 Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Ibaraki, Japan.
PMID: 7592017 DOI: 10.7164/antibiotics.48.757
Abstract

FR901537 is a new aromatase inhibitor produced by a bacterium Bacillus sp. No. 3072. Structural studies of FR901537 suggested that it was a novel naphthol derivative having pantetheine in its structure. FR901537 showed a potent inhibitory activity against aromatase from human placenta or rat ovary, but did not inhibit the activity of 11 beta-hydroxylase from bovine adrenal cortex. Lineweaver-Burk plot analysis revealed that FR901537 is a competitive inhibitor.

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