2. Metabolic Enzyme/Protease Neuronal Signaling Membrane Transporter/Ion Channel
  3. Acyltransferase Calcium Channel
  4. Monatepil maleate

Monatepil maleate  (Synonyms: AJ-2615)

目录号: HY-106818A
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摩尔计算器

Monatepilmaleate (AJ-2615) 是一种有效的具有口服活性的 Ca2+-通道 拮抗剂和非竞争性 ACAT 抑制剂。Monatepilmaleate 可降低血压并改善血浆脂质代谢。Monatepilmaleate 具有研究高脂血症的潜力。

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Monatepil maleate Chemical Structure

Monatepil maleate Chemical Structure

CAS No. : 103379-03-9

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Monatepil maleate 相关抗体

Top Publications Citing Use of Products

查看 Acyltransferase 亚型特异性产品:

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ACAT1 ACAT2 MGAT2 ACAT

查看 Calcium Channel 亚型特异性产品:

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Monatepil maleate (AJ-2615) is a potent and orally active Ca2+-channel antagonist and a noncompetitive ACAT inhibitor. Monatepil maleate decreases blood pressure and improves plasma lipid metabolism. Monatepil maleate has the potential for the research of hyperlipidemia[1][2].

体内研究
(In Vivo)

Monatepil maleate (30 mg/kg; p.o.; once daily for 9 weeks) 可改善血浆脂质代谢[1]。
Monatepil maleate (30 mg/kg; p.o.; once daily for 6 weeks) 可抑制高胆固醇饮食猴子的 ACAT 活性和酯化胆固醇含量[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 8 weeks, Male japanese white rabbits (high cholesterol diet-fed)[1]
Dosage: 30 mg/kg
Administration: P.o.; once daily for 9 weeks
Result: Improved plasma lipid metabolism and reduced atherosclerotic lesions, decreased blood pressure.
Animal Model: 4-7 kg, 4-7 years monkeys (high cholesterol diet for 6 months)[2]
Dosage: 30 mg/kg
Administration: P.o.; once daily for 6 weeks
Result: Inhibited the increases of ACAT activity and esterified cholesterol content.
分子量

591.69

Formula

C32H34FN3O5S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Monatepil maleate 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Monatepil103379-03-9AJ-2615AJ2615AJ 2615AcyltransferaseCalcium ChannelDiacylglycerol acyltransferaseDiglyceride acyltransferaseacyl-CoA:cholesterol acyltransferasemono- acylglycerol acyltransferaseCa2+ channelsCa channelshyperlipidemiaorally activeblood pressurelipid metabolismInhibitorinhibitorinhibit

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