2. Cell Cycle/DNA Damage
  3. Checkpoint Kinase (Chk)
  4. MU380

MU380 是一种强效的、选择性 CHK1 抑制剂，可以诱导细胞凋亡 (apoptosis)，具有抗癌活性。

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MU380 Chemical Structure

MU380 Chemical Structure

CAS No. : 2109805-78-7

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     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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MU380 相关抗体

Top Publications Citing Use of Products

查看 Checkpoint Kinase (Chk) 亚型特异性产品:

查看所有亚型
Chk1 Chk2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MU380 is a potent and selective CHK1 inhibitor that induces apoptosis and has anticancer activity[1].

体外研究
(In Vitro)

MU380 (100 nM, 24 h) 有效抑制 CHK1 激酶并使淋巴肿瘤细胞对吉西他滨敏感[1]。
MU380 (400 nM, 24 h) 可以显着影响细胞周期概况，诱导分裂和非分裂原发性慢性淋巴细胞白血病淋巴细胞死亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MU380 相关抗体:

Apoptosis Analysis[1]

Cell Line: MEC-1and MEC-2 cells
Concentration: 400 nM
Incubation Time: 24 h
Result: Showed accumulation in S phase as well as reduction in G2/M phase, greatly reduced rate of DNA synthesis, and marked induction of apoptosis (PARP protein cleavage).

Western Blot Analysis[1]

Cell Line: Chronic lymphocytic leukemia cells
Concentration: 100 nM or 200 nM
Incubation Time: 24 h
Result: Potently blocked CHK1 activation while enhancing ATR kinase signaling to CHK1 (pS317 and pS345), and resulted in decreased levels of total CDC25A and CDC25C, pY15 CDK1, cyclin B1 and cyclin E1.
体内研究
(In Vivo)

MU380 (20 mg/kg, 使用20% aqueous Kolliphor 溶液, 从第 14天 到第 28 天，每 3 天使用一次) 可以有效抑制小鼠肿瘤的生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NOD-scid IL2Rγnull mice[1]
Dosage: 20 mg/kg
Administration: In 20% aqueous Kolliphor solution, every three days from day 14 to day 28
Result: Significantly inhibit the growth of tumors and gradually reduce their volume, with an average reduction of about 61%.
分子量

430.23

Formula

C15H15BrF3N7
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MU380 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MU3802109805-78-7MU 380MU-380Checkpoint Kinase (Chk)CHK1apoptosisanticancerInhibitorinhibitorinhibit

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目录号：
HY-112927
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