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  4. NSC1011

NSC1011 是一种有效的 Ras 转化酶 1 内蛋白酶 (Ras converting enzyme 1 endoprotease (Rce1)) 抑制剂，对 HsRce1 的 IC50 值为 6.9 µM。NSC1011 可诱导 EGFR-H-Ras、EGFR-N-Ras 和 EGFR-K-Ras 的错误定位。

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NSC1011 Chemical Structure

NSC1011 Chemical Structure

CAS No. : 5335-97-7

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NSC1011 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NSC1011 is a potent Ras converting enzyme 1 endoprotease (Rce1) inhibitor with an IC50 value of 6.9 µM for HsRce1 (crystal structure of the human Rce1). NSC1011 induces mislocalizing EGFR-H-Ras, EGFR-N-Ras, and EGFR-K-Ras[1].

IC50 & Target

IC50: 6.9 µM (Rce1)[1]
体外研究
(In Vitro)

NSC1011 (25 µM; 20 h) 会在 HCT-116 细胞中诱导 EGFR-H-Ras、EGFR-N-Ras 和 EGFR-K-Ras 错误定位[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

NSC1011 相关抗体:
分子量

370.40

Formula

C23H18N2O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

NSC1011 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NSC10115335-97-7NSC 1011NSC-1011OthersHCT-116 cellsmislocalizingEGFR-H-RasEGFR-N-RasEGFR-K-RasInhibitorinhibitorinhibit

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目录号：
HY-122079
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