2. GPCR/G Protein
  3. Prostaglandin Receptor
  4. ONO-8711

ONO-8711 是一种有效且选择性的 EP1 受体竞争性拮抗剂(对人和小鼠 EP1 的 Ki分别为 0.6 和 1.7 nM)。ONO-8711 有效降低结肠癌、乳腺癌和口腔癌小鼠模型中的肿瘤发生率和多样性。

在相同的摩尔浓度下，化合物盐形式与游离形式有相同的生物活性，但盐形式 ONO-8711 dicyclohexylamine 通常具有更好的水溶性和稳定性。

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ONO-8711 Chemical Structure

ONO-8711 Chemical Structure

CAS No. : 216158-34-8

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规格 是否有货
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100 mg   询价  
250 mg   询价  

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ONO-8711 的其他形式现货产品:

Other Forms of ONO-8711:

ONO-8711 相关抗体

Top Publications Citing Use of Products

查看 Prostaglandin Receptor 亚型特异性产品:

查看所有亚型
DP EP FP IP TXA2/TP TXB2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ONO-8711 is a potent and selective competitive antagonist of EP1 receptor (Ki = 0.6 and 1.7 nM for human and mouse EP1 respectively). ONO-8711 effectively reduces tumor incidence and multiplicity in mouse models of colon, breast, and oral cancer[1].

IC50 & Target

EP

 

体外研究
(In Vitro)

ONO-8711 (10 and 30 μM; 30 min) blocks the contractions induced by sulprostone in human pulmonary veins in a non-competitive manner[2].
ONO-8711 inhibits PGE2-induced increase in cytosolic Ca2+ concentration with IC50s of 0.21 μM, 0.05 μM, and 0.22 μM for the mouse, human, and rat receptors, respectively[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ONO-8711 相关抗体:
体内研究
(In Vivo)

ONO-8711 (400 or 800 p.p.m.; p.o.; for 20 weeks) suppresses cancer incidence and delays occurrence of breast tumors[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Sprague-Dawley rats (induced breast cancer by gavage of 85 mg/kg PhIP (HY-118716) 4 times for 2 weeks)
Dosage: 400 or 800 p.p.m.
Administration: p.o.; for 20 weeks
Result: Did not induce any symptoms of toxicity at 800 p.p.m..
Delayed occurrence of breast tumors for 2 or 4 weeks at 400 or 800 p.p.m., respectively.
Significantly suppressed cancer incidence compared with the control diet group at 800 p.p.m. (56% versus 79%, P < 0.05).
分子量

440.00

Formula

C22H30ClNO4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ONO-8711 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ONO-8711216158-34-8ONO8711ONO 8711Prostaglandin ReceptorEP1breast cancergavageanticancerInhibitorinhibitorinhibit

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产品名称：
ONO-8711
目录号：
HY-12182
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