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  4. OX01914

OX01914 是一种具有良好水溶性和细胞膜渗透性的 utrophin 调节剂 (上调 utrophin 蛋白水平)，其 EC50 值为 20.5 μM. OX01914 可用于杜兴氏肌肉营养不良症的研究。

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OX01914 Chemical Structure

OX01914 Chemical Structure

CAS No. : 49676-35-9

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OX01914 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

OX01914 is a water-solube and permeable utrophin modulator (upregulates utrophin protein levels), with an EC50 of 20.5 μM. OX01914 can be used in study of duchenne muscular dystrophy (DMD)[1].

体外研究
(In Vitro)

OX01914 (0.1, 10, 40, 50 µM; 24 h) upregulates utrophin mRNA in LUmdx and (30 µM; 24 h) H2K mdx myoblasts[1].
OX01914 (1, 3, 30; 24 h) upregulates utrophin protein levels in human DMD muscle cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

OX01914 相关抗体:

Western Blot Analysis[1]

Cell Line: LUmdx and H2K mdx myoblasts
Concentration: 0.1, 10, 40, 50 µM (for LUmdx myoblasts) ; 30 µM (for H2K mdx myoblasts).
Incubation Time: 24 h
Result: Upregulated utrophin mRNA both in LUmdx and H2K mdx myoblasts.

Western Blot Analysis[1]

Cell Line: Human DMD cells
Concentration: 1, 3, 30 µM
Incubation Time: 24 h
Result: Increased utrophin protein levels by approximately 3-fold.
分子量

290.32

Formula

C17H14N4O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

OX01914 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

OX0191449676-35-9OX 01914OX-01914Othersduchenne muscular dystrophyDMDutrophin proteinLUmdx myoblastsH2K mdx myoblastsDMD cellsInhibitorinhibitorinhibit

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目录号：
HY-150078
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