2. PROTAC
  3. PROTAC Linkers
  4. Propargyl-PEG4-O-C1-NHS ester

Propargyl-PEG4-O-C1-NHS ester 

目录号: HY-130390
产品使用指南

摩尔计算器

Propargyl-PEG4-O-C1-NHS ester (compound 8) 是一种 PROTAC linker，属于 PEG 类。Propargyl-PEG4-O-C1-NHS ester 可用于合成一系列 PROTAC 分子。Propargyl-PEG4-O-C1-NHS ester 是一种点击化学试剂。它含有 Alkyne 基团，可以和含有 Azide 基团的分子发生铜催化的叠氮-炔环加成反应 (CuAAc)。

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Propargyl-PEG4-O-C1-NHS ester Chemical Structure

Propargyl-PEG4-O-C1-NHS ester Chemical Structure

CAS No. : 1161883-51-7

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规格 价格 是否有货
25 mg ￥1036
询问价格 & 货期
50 mg ￥1666
询问价格 & 货期
100 mg ￥2892
询问价格 & 货期
500 mg ￥5340
询问价格 & 货期
1 g 现货 询问价格 & 货期

* Please select Quantity before adding items.

Customer Review

Propargyl-PEG4-O-C1-NHS ester 相关抗体

Top Publications Citing Use of Products

查看 PROTAC Linkers 亚型特异性产品:

查看所有亚型
PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Propargyl-PEG4-O-C1-NHS ester (compound 8) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG4-O-C1-NHS ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC50 & Target[1]

PEGs

 

Alkyl/ether

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Propargyl-PEG4-O-C1-NHS ester 相关抗体:
分子量

387.38

Formula

C17H25NO9
CAS 号
性状

粘稠液体

颜色

Colorless to light brown

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Pure form -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料
参考文献

Propargyl-PEG4-O-C1-NHS ester 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Propargyl-PEG4-O-C1-NHS ester1161883-51-7PROTAC LinkersPEGPROTAClinkerE3ubiquitinligaseproteinInhibitorinhibitorinhibit

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Propargyl-PEG4-O-C1-NHS ester
目录号：
HY-130390
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